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SPOP-mediated proteasomal degradation of PD-L1(CD274)

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9929491

PubChem

R-HSA-9929491

Description

SPOP:CUL3:RBX1 E3 ubiquitin ligase complex regulates the ubiquitination and degradation of PD-L1(CD274) protein. This is negatively regulated by Cyclin D:CDK4 complex which phosphorylates SPOP on Ser-6 (S6) and facilitates its sequestration by 14-3-3 protein gamma (Zhang et al., 2018), thus inhibiting SPOP-mediated recruitment in the E3 ubiquitin ligase complex.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 28 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00231	26S proteasome non-ATPase regulatory subunit 11	PSMD11	view
O00487	Ubiquitin C-terminal hydrolase PSMD14	POH1 PSMD14	view
O14818	Proteasome subunit alpha type-7	HSPC PSMA7	view
O43242	26S proteasome non-ATPase regulatory subunit 3	PSMD3	view
O43791	Speckle-type POZ protein	SPOP	view
P17980	26S proteasome regulatory subunit 6A	PSMC3 TBP1	view
P19784	Casein kinase II subunit alpha'	CK2A2 CSNK2A2	view
P20618	Proteasome subunit beta type-1	PSC5 PSMB1	view
P25786	Proteasome subunit alpha type-1	HC2 NU PROS30 PSC2 PSMA1	view
P25788	Proteasome subunit alpha type-3	HC8 PSC8 PSMA3	view

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