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PD-L1(CD274) glycosylation and translocation to plasma membrane

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9931295

PubChem

R-HSA-9931295

Description

PD-L1 (CD274) glycosylation plays a critical role in determining the protein function and stability. PD-L1 is N-glycosylated at N192, N200 and N219 by the OST complex in the ER lumen. This process is important for PD-L1 stability and inhibits its targeting for proteasomal degradation by GSK3B (Li et al., 2016). Also, JAK1 activated by IL6 pathway positively regulates the glycosylation process by aiding in the process of recruiting endoplasmic reticulum-associated N-glycosyltransferase STT3A (part of the OST complex) to catalyse PD-L1 glycosylation (Chan et al., 2019). PD-L1 is phosphorylated by IL6-activated JAK1 at Tyr112 (Y112). This process aids in stabilizing the PD-L1 protein. PD-L1, once glycosylated in the ER lumen, get translocated to the Golgi complex for further glycosylation by B3GNT3 (Li et al., 2018) and K63-ubiquitination by MIB2 (Yu et al., 2023). Post Golgi, PD-L1 gets transported to the plasma membrane where it can bind with its receptor and induce immune tolerance.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 13 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P04843	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	RPN1	view
P04844	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2	RPN2	view
P23458	Tyrosine-protein kinase JAK1	JAK1 JAK1A JAK1B	view
P46977	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A	ITM1 STT3A TMC	view
P62979	Ubiquitin-ribosomal protein eS31 fusion protein	RPS27A UBA80 UBCEP1	view
P62987	Ubiquitin-ribosomal protein eL40 fusion protein	UBA52 UBCEP2	view
Q13454	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3	N33 TUSC3	view
Q15116	Programmed cell death protein 1	PD1 PDCD1	view
Q8TCJ2	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B	SIMP STT3B	view
Q9BQ51	Programmed cell death 1 ligand 2	B7DC CD273 PDCD1L2 PDCD1LG2 PDL2	view

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