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Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

Summary

UniProt ID: P46977
Gene Symbol: ITM1 STT3A TMC
Gene ID: 3703
Organism: Homo sapiens (human)

External Links

GlyConnect

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

GlyGen

P46977

PubChem

P46977

The Human Metabolome Database

HMDBP02781

The O-GlcNAc Database

P46977

RaftProt

P46977

O-GlcNAcAtlas

P46977

Re-Glyco

P46977

Annotation

Keyword: 3D-structure Alternative splicing Congenital disorder of glycosylation Disease variant Endoplasmic reticulum Glycoprotein Glycosyltransferase Magnesium Manganese Metal-binding Proteomics identification Reference proteome Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
protein N-linked glycosylation	ISS	GO_REF
protein N-linked glycosylation	NAS	PMID
protein N-linked glycosylation	IDA	PMID PMID
protein N-linked glycosylation	IMP	PMID PMID
obsolete protein N-linked glycosylation via asparagine

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

protein modification process [inference]

post-translational protein modification

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

protein modification process [inference]

post-translational protein modification

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

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GO Term	Evidence Code	Reference
endoplasmic reticulum membrane	ISS	GO_REF
endoplasmic reticulum membrane	NAS	PMID
endoplasmic reticulum membrane	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome
endoplasmic reticulum membrane	IEA	GO_REF
oligosaccharyltransferase complex	ISS	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase complex A

endoplasmic reticulum protein-containing complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase complex A

catalytic complex [inference]

transferase complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase complex A

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	ISS	GO_REF
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	TAS	Reactome
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IDA	PMID PMID PMID
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IMP	PMID PMID
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

oligosaccharyl transferase activity [inference]

dolichyl-diphosphooligosaccharide-protein glycotransferase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MTKFGFLRLSYEKQDTLLKLLILSMAAVLSFSTRLFAVLRFESVIHEFDPYFNYRTTRFLAEEGFYKFHNWFDDRAWYPLGRIIGGTIYPGLMITSAAIYHVLHFFHITIDIRNVCVFLAPLFSSFTTIVTYHLTKELKDAGAGLLAAAMIAVVPGYISRSVAGSYDNEGIAIFCMLLTYYMWIKAVKTGSICWAAKCALAYFYMVSSWGGYVFLINLIPLHVLVLMLTGRFSHRIYVAYCTVYCLGTILSMQISFVGFQPVLSSEHMAAFGVFGLCQIHAFVDYLRSKLNPQQFEVLFRSVISLVGFVLLTVGALLMLTGKISPWTGRFYSLLDPSYAKNNIPIIASVSEHQPTTWSSYYFDLQLLVFMFPVGLYYCFSNLSDARIFIIMYGVTSMYFSAVMVRLMLVLAPVMCILSGIGVSQVLSTYMKNLDISRPDKKSKKQQDSTYPIKNEVASGMILVMAFFLITYTFHSTWVTSEAYSSPSIVLSARGGDGSRIIFDDFREAYYWLRHNTPEDAKVMSWWDYGYQITAMANRTILVDNNTWNNTHISRVGQAMASTEEKAYEIMRELDVSYVLVIFGGLTGYSSDDINKFLWMVRIGGSTDTGKHIKENDYYTPTGEFRVDREGSPVLLNCLMYKMCYYRFGQVYTEAKRPPGFDRVRNAEIGNKDFELDVLEEAYTTEHWLVRIYKVKDLDNRGLSRT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
124		29351928 30059200 32119511 34019948 34725712 34846842 35083852 35254053 38665916 39302247 39531497 39534244 40596516	G49108TO	The O-GlcNAc Database
537	N-linked (GlcNAc...) asparagine	19159218 24190977 29741879 37074911	G51653BI G83460ZZ G70223PD G59626AS G46503DX G01650EU G23294PN G48584BU G70101JE G80920RR G73968GN G62765YT G64527OM G11870QZ G88891KO G31852PQ	UniProt GlyGen GlyConnect
539		29351928 30059200 32119511 34019948 34725712 34846842 35083852 35254053 38665916 39302247 39531497 39534244 40596516	G49108TO	GlyGen The O-GlcNAc Database
544	N-linked (GlcNAc...) asparagine	19159218 24190977 29741879 37074911	G36442WJ G15664MX G66621EA G83460ZZ G49018RC G35253PZ G72747WU G46503DX G70101JE G80920RR G14260UH G62765YT G64527OM G31852PQ G54010QB	UniProt GlyGen GlyConnect
545		24190977		GlyGen
546		29351928 30059200 32119511 34019948 34725712 34846842 35083852 35254053 38665916 39302247 39531497 39534244 40596516	G49108TO	GlyGen The O-GlcNAc Database
548	N-linked (GlcNAc...) (high mannose) asparagine	19159218 23090970 24190977 29741879	G46503DX G80920RR G62765YT	UniProt GlyGen
549		24190977		GlyGen
550		29351928 30059200 32119511 34019948 34725712 34846842 35083852 35254053 38665916 39302247 39531497 39534244 40596516	G49108TO	GlyGen The O-GlcNAc Database
553		29351928 30059200 32119511 34019948 34725712 34846842 35083852 35254053 38665916 39302247 39531497 39534244 40596516	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Asparagine N-linked glycosylation	Homo sapiens
Maturation of DENV proteins	Homo sapiens
Maturation of spike protein	Homo sapiens
PD-L1(CD274) glycosylation and translocation to plasma membrane	Homo sapiens
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080572	congenital disorder of glycosylation Iw	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

Annotation

International Collaboration

Acknowledgements