GlyCosmos Portal

Submissions

Maturation of DENV proteins

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9918432

PubChem

R-HSA-9918432

Description

Dengue virus (DENV) uses the host to fold and cleave its polyprotein, and mature the resulting fragments. The individual steps are highly conserved in all flaviviruses. The proteins prM, E, and NS1 are glycosylated with complex glycans or high-mannose sugars (reviewed in Yap et al., 2017; Feng et al., 2022). Dengue proteins can undergo further modifications like phosphorylation, sumoylation, ubiquitination, myristoylation or hydroxyprolylation (Aviner et al., 2021; reviewed in Kumar et al., 2020; Boytz & Rolle, 2024). C and NS5 also localize to the nucleus, and NS1 is secreted to extracellular space, where they interact with host factors. NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5 form the replication complex at foci near the ER membrane which later supports budding of virions into the ER lumen (reviewed in Cleaves, 1985; Roby et al., 2015).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 31 in total

1

2

3

4

Next ›

Last »
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14980	Exportin-1	CRM1 XPO1	view
O15460	Prolyl 4-hydroxylase subunit alpha-2	P4HA2 UNQ290/PRO330	view
O95373	Importin-7	IPO7 RANBP7	view
P02647	Apolipoprotein A-I	APOA1	view
P04843	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	RPN1	view
P04844	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2	RPN2	view
P07237	Protein disulfide-isomerase	ERBA2L P4HB PDI PDIA1 PO4DB	view
P11021	Endoplasmic reticulum chaperone BiP	GRP78 HSPA5	view
P13674	Prolyl 4-hydroxylase subunit alpha-1	P4HA P4HA1	view
P27797	Calreticulin	CALR CRTC	view

Displaying **all 6** entries
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_000249	P27824	Calnexin	view
GL_000272	P27797	Calreticulin	view
GL_004645	O60762	Dolichol-phosphate mannosyltransferase subunit 1	view
GL_005149	O15460	Prolyl 4-hydroxylase subunit alpha-2	view
GL_005207	P13674	Prolyl 4-hydroxylase subunit alpha-1	view
GL_005280	Q7Z4N8	Prolyl 4-hydroxylase subunit alpha-3	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.