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Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9934037

PubChem

R-HSA-9934037

Description

Studies in mice have identified two distinct BAF complexes that regulate neuronal differentiation, exemplifying the combinatorial control of BAF activity through changes to complex composition (reviewed in Staahl and Crabtree, 2013; Kadoch and Crabtree, 2015; Innis and Cabot, 2020; Cenik and Shilatifard, 2021. Neuronal progenitor and neural stem cells contain an npBAF complex that is required for multipotency and proliferation; this complex is characterized by the presence of ACTL6A, SS18 and BAF45 family members DPF2 or PHF10 (Lessard et al, 2007; Staahl et al, 2013). Mature neurons that have exited the cell cycle, in contrast, contain a nBAF complex characterized by ACTL6B, the SS18 family member SS18L1 and DPF45 family members DPF1 and DPF3 (Lessard et al, 2007; Staahl et al, 2013).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 17 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14497	AT-rich interactive domain-containing protein 1A	ARID1A BAF250 BAF250A C1orf4 OSA1 SMARCF1	view
O75177	Calcium-responsive transactivator	CREST KIAA0693 SS18L1	view
O96019	Actin-like protein 6A	ACTL6A BAF53 BAF53A INO80K	view
P51531	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2	BAF190B BRM SMARCA2 SNF2A SNF2L2	view
P51532	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4	BAF190A BRG1 SMARCA4 SNF2B SNF2L4	view
P60709	Actin, cytoplasmic 1	ACTB	view
Q12824	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	BAF47 INI1 SMARCB1 SNF5L1	view
Q15532	Protein SSXT	SS18 SSXT SYT	view
Q8NFD5	AT-rich interactive domain-containing protein 1B	ARID1B BAF250B DAN15 KIAA1235 OSA2	view
Q8TAQ2	SWI/SNF complex subunit SMARCC2	BAF170 SMARCC2	view

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