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Developmental Lineage of Multipotent Pancreatic Progenitor Cells

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9937080

PubChem

R-HSA-9937080

Description

Definitive endoderm forms during gastrulation and then undergoes patterning along anterior/posterior, dorsal/ventral, and median/lateral axes. Definitive endoderm cells produce, among other embryonal cell types, endoderm cells of dorsal and ventral foregut. The dorsal foregut endoderm cells, which transition through an intermediary duodeno-pancreatic endoderm cell state, and the ventral foregut endoderm cells, which possibly transition through a hepato-pancreatic or pancreato-biliary intermediary state, give rise to primary multipotent pancreatic progenitor cells (MPCs) that form dorsal and ventral pancreatic buds, respectively (Yu et al. 2019, reviewed in Jennings et al. 2015).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 9** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15520	Fibroblast growth factor 10	FGF10	view
O95813	Cerberus	CER1 DAND4	view
P01133	Pro-epidermal growth factor	EGF	view
P21781	Fibroblast growth factor 7	FGF7 KGF	view
P43694	Transcription factor GATA-4	GATA4	view
P48436	Transcription factor SOX-9	SOX9	view
P61073	C-X-C chemokine receptor type 4	CXCR4	view
Q15465	Sonic hedgehog protein	SHH	view
Q9UBC0	Hepatocyte nuclear factor 6	HNF6 HNF6A ONECUT1	view

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