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Guidelines

MIRAGE

cathepsin D

Summary

Gene Symbol

Ctsd

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13033

KEGG Gene ID

PubChem

13033

Alliance of Genome Resources

MGI:88562

Annotation

Keyword

Aspartyl protease
Disulfide bond
Glycoprotein
Lysosome
Reference proteome
Secreted
Signal
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P18242
Q3UCD9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
autophagosome assembly	IMP
proteolysis	ISO
proteolysis	IC
proteolysis	IBA
proteolysis	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

proteolysis

protein catabolic process

lipoprotein metabolic process [inference]

lipoprotein catabolic process

insulin metabolic process [inference]

insulin catabolic process

receptor metabolic process [inference]

receptor recycling [inference]

insulin receptor recycling

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process

lipoprotein metabolic process [inference]

lipoprotein catabolic process

insulin metabolic process [inference]

insulin catabolic process

vesicle-mediated transport [inference]

endosomal transport [inference]

synaptic vesicle endosomal processing

vesicle-mediated transport in synapse

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

synaptic vesicle endosomal processing

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

cellular component assembly [inference]

organelle assembly [inference]

autophagosome assembly

execution phase of apoptosis

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

synaptic vesicle endosomal processing

vesicle-mediated transport in synapse

intracellular transport [inference]

endosomal transport [inference]

synaptic vesicle endosomal processing

establishment of localization in cell [inference]

intracellular transport [inference]

endosomal transport [inference]

synaptic vesicle endosomal processing

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

synaptic vesicle endosomal processing

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

Displaying entries **6 - 10** of 23 in total

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GO Term	Evidence Code	PMID
lysosome	ISO
lysosome	IDA
lysosome	IBA
lysosome	IEA
lysosomal membrane	ISO

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

synapse [inference]

GABA-ergic synapse

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endosome lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

presynaptic endosome

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

presynaptic endosome

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

presynaptic endosome

pigment granule [inference]

melanosome

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GO Term	Evidence Code	PMID
endopeptidase activity	ISO
endopeptidase activity	IDA
endopeptidase activity	IEA
aspartic-type endopeptidase activity	IDA
aspartic-type endopeptidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

peptidase activity

endopeptidase activity

aspartic-type endopeptidase activity

aspartic-type peptidase activity

aspartic-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

aspartic-type endopeptidase activity

aspartic-type peptidase activity

aspartic-type endopeptidase activity

binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110725	neuronal ceroid lipofuscinosis 10	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	1509	HGNC:2529
Rattus norvegicus	171293	RGD:621511
Caenorhabditis elegans	181444	WB:WBGene00000217
Saccharomyces cerevisiae S288C	855949	SGD:S000006075

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026