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fibroblast growth factor receptor 4

Summary

Gene Symbol

FGFR4

Organism

Homo sapiens (human)

External Links

NCBI Gene

2264

KEGG Gene ID

PubChem

2264

Alliance of Genome Resources

HGNC:3691

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P22455
J3KPQ0
B4DVP5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	IDA
positive regulation of cell population proliferation	IGI
positive regulation of cell population proliferation	IBA
positive regulation of cell population proliferation	IEA
fibroblast growth factor receptor signaling pathway	TAS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

cell motility [inference]

cell migration

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

inorganic ion homeostasis [inference]

phosphate ion homeostasis

response to stimulus [inference]

response to chemical [inference]

response to lipid [inference]

response to bile acid

response to oxygen-containing compound [inference]

response to bile acid

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

regulation of DNA biosynthetic process [inference]

positive regulation of DNA biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of bile acid biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

regulation of ketone metabolic process [inference]

regulation of bile acid biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

regulation of DNA biosynthetic process [inference]

positive regulation of DNA biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

regulation of DNA metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process

regulation of DNA biosynthetic process [inference]

positive regulation of DNA biosynthetic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

regulation of small molecule metabolic process [inference]

regulation of bile acid biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process

regulation of steroid metabolic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of bile acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of bile acid biosynthetic process

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process

regulation of DNA biosynthetic process [inference]

positive regulation of DNA biosynthetic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of cellular component organization [inference]

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA
plasma membrane	IBA
plasma membrane	IEA
cell-cell junction	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

extracellular region

membrane

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
protein kinase activity	IEA
protein tyrosine kinase activity	IEA
transmembrane receptor protein tyrosine kinase activity	IEA
fibroblast growth factor receptor activity	TAS
fibroblast growth factor receptor activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

binding [inference]

protein binding

growth factor binding [inference]

fibroblast growth factor binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

sulfur compound binding [inference]

heparin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

fibroblast growth factor receptor

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
ATP binding
fibroblast growth factor receptor activity
fibroblast growth factor receptor signaling pathway
nucleotide binding
positive regulation of cell population proliferation
transmembrane receptor protein tyrosine kinase activity

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InterPro
Fibroblast growth factor receptor family
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:3748	esophagus squamous cell carcinoma	Alliance of Genome Resources
DOID:3910	lung adenocarcinoma	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:5520	head and neck squamous cell carcinoma	Alliance of Genome Resources
DOID:3907	lung squamous cell carcinoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:0050866	oral squamous cell carcinoma	Alliance of Genome Resources

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	14186	MGI:95525
Rattus norvegicus	25114	RGD:2612
Drosophila melanogaster	42160	FB:FBgn0010389
Drosophila melanogaster	39564	FB:FBgn0285896
Danio rerio	100000160	ZFIN:ZDB-GENE-980526-488

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements