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major histocompatibility complex, class I-related

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25119

PubChem

25119

Alliance of Genome Resources

RGD:1593291

Annotation

Keyword

Cell membrane
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Immunoglobulin domain
Innate immunity
MHC I
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O19477	MHC class I-related gene protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
antigen processing and presentation of peptide antigen via MHC class I	IEA
positive regulation of T cell mediated cytotoxicity directed against tumor cell target	ISO
positive regulation of T cell mediated cytotoxicity directed against tumor cell target	IEA
immune response	IBA
antigen processing and presentation of exogenous antigen	ISO

GO Hierarchy

biological process

immune system process [inference]

immune response

innate immune response

antigen processing and presentation [inference]

antigen processing and presentation of exogenous antigen

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of peptide antigen via MHC class I

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

immune response

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of leukocyte mediated immunity [inference]

regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of response to tumor cell [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response to tumor cell [inference]

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of immune response to tumor cell [inference]

positive regulation of T cell mediated immune response to tumor cell [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of cellular process [inference]

regulation of cell killing [inference]

regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity directed against tumor cell target

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO
external side of plasma membrane	IBA
early endosome membrane	ISO
early endosome membrane	IEA
late endosome membrane	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

MHC protein complex [inference]

MHC class I protein complex

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

endosome membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
beta-2-microglobulin binding	ISO
beta-2-microglobulin binding	IEA
T cell receptor binding	ISO
T cell receptor binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

T cell receptor binding

beta-2-microglobulin binding

protein-containing complex binding [inference]

T cell receptor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

class i histocompatibility

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
immune response

Displaying **all 4** entries
InterPro
Immunoglobulin C1-set
MHC class I-like antigen recognition-like superfamily
MHC class I-like antigen recognition-like
MHC classes I/II-like antigen recognition protein

Ortholog

Displaying entries **31 - 40** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	15064	Xenbase:XB-GENE-5873924	MOUSE27557
Xenopus tropicalis	15216	Xenbase:XB-GENE-5873924
Xenopus tropicalis	25119	Xenbase:XB-GENE-5873924
Xenopus tropicalis	29199	Xenbase:XB-GENE-5873924
Xenopus tropicalis	29558	Xenbase:XB-GENE-484711
Xenopus tropicalis	68395	Xenbase:XB-GENE-5873924
Xenopus tropicalis	110557	Xenbase:XB-GENE-5873924
Xenopus tropicalis	243864	Xenbase:XB-GENE-484711
Xenopus tropicalis	365212	Xenbase:XB-GENE-484711
Pan troglodytes	457562		PANTR23156

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements