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fucosyltransferase 6

Summary

Gene Symbol

FUT6

Aliases

FCT3A
FLJ40754
FT1A
FucT-VI
alpha-(1,3)-fucosyltransferase
galactoside 3-L-fucosyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

2528

GGDB ID

gg006

HGNC

4017

mRNA

NM_000150

map

19p13.3

Protein

NP_000141

OMIM

136836

KEGG Gene ID

hsa:2528

PubChem

2528

Alliance of Genome Resources

HGNC:4017

JoGo

FUT6

TogoVar

FUT6

Annotation

Keyword

Alternative splicing
Direct protein sequencing
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Proteomics identification
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6P7E6
P51993	Fucosyltransferase 6 Fucosyltransferase VI Galactoside 3-L-fucosyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
protein N-linked glycosylation	IDA
protein O-linked glycosylation	IDA
sphingolipid metabolic process	IEA
ceramide metabolic process	IDA
glycosphingolipid biosynthetic process	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

L-fucose catabolic process

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

L-fucose catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein O-linked glycosylation

protein O-linked glycosylation via fucose

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein O-linked glycosylation

protein O-linked glycosylation via fucose

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein O-linked glycosylation

protein O-linked glycosylation via fucose

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein O-linked glycosylation

protein O-linked glycosylation via fucose

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process [inference]

L-fucose metabolic process [inference]

L-fucose catabolic process

hexose catabolic process [inference]

L-fucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

L-fucose catabolic process

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

L-fucose catabolic process

lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein O-linked glycosylation

protein O-linked glycosylation via fucose

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process [inference]

L-fucose metabolic process [inference]

L-fucose catabolic process

hexose catabolic process [inference]

L-fucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

L-fucose catabolic process

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

L-fucose catabolic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein O-linked glycosylation

protein O-linked glycosylation via fucose

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein O-linked glycosylation

protein O-linked glycosylation via fucose

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

reproductive process [inference]

developmental process involved in reproduction [inference]

oocyte axis specification

multicellular organismal process [inference]

pattern specification process [inference]

axis specification [inference]

oocyte axis specification

developmental process [inference]

developmental process involved in reproduction [inference]

oocyte axis specification

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
Golgi membrane	IEA
extracellular region	IDA
extracellular region	IBA
extracellular region	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

methyltransferase complex [inference]

methylosome

cellular anatomical structure [inference]

extracellular region

membrane

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
fucosyltransferase activity	TAS
fucosyltransferase activity	IDA
fucosyltransferase activity	IEA
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IDA
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

fucosyltransferase activity

alpha-(1->3)-fucosyltransferase activity

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000156413

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg006

Gene Symbol

FUT6

Reactions

Displaying entries **1 - 5** of 8 in total

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Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
GDP-Fuc	G97494HI	O-glycan Synthesis	G94541HG	O-glycan Synthesis
GDP-Fuc	G61459JW	(CH2)8COOCH3	G00052MO	(CH2)8COOCH3	9079712
GDP-Fuc	G64844ET	O-glycan Synthesis	G88696BY	O-glycan Synthesis
GDP-Fuc	G32723SL	O-glycan Synthesis	G02522JF	O-glycan Synthesis
GDP-Fuc	G64973KT	O-glycan Synthesis	G17752YB	O-glycan Synthesis

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Reference
GDP-Fuc	G40696TO	(CH2)8COOCH3	9079712

Orthologous Gene

Displaying 1 entry
Species	Protein	mRNA
Drosophila melanogaster	AAL48946	AY071324

KEGG BRITE Database

Orthology

K07634

Name

galactoside alpha-1,3-fucosyltransferase 6 [EC:2.4.1.65]

References

1520296

Reactions

Displaying entries **1 - 10** of 11 in total

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KEGG Reaction	Enzyme	Acceptor	Product
R06038	2.4.1.- 2.4.1.152 2.4.1.65	G84034JH	G76439VL
R06230	2.4.1.- 2.4.1.152 2.4.1.65	G84034JH	G65223RT
R06221	2.4.1.- 2.4.1.152 2.4.1.65	G76439VL	G91560NT
R06222	2.4.1.- 2.4.1.152 2.4.1.65	G00851XQ	G52160KJ
R06075	2.4.1.- 2.4.1.65	G01767JJ	G96401FK
R06025	2.4.1.- 2.4.1.152 2.4.1.65	G58896AZ	G72002FC
R06227	2.4.1.- 2.4.1.152 2.4.1.65	G07075ZE	G03564IA
R06076	2.4.1.- 2.4.1.152 2.4.1.65	G66427ZQ	G07075ZE
R06224	2.4.1.- 2.4.1.152 2.4.1.65	G52160KJ	G20180GO
R06095	2.4.1.- 2.4.1.152 2.4.1.65	G13636IT	G89659QV

Rhea

RHEA:14257

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose

a β-D-galactosyl-(1→4)-[α-L-fucosyl-(1→3)]-N-acetyl-β-D-glucosaminyl derivative + H⁺ + GDP

Enzyme

2.4.1.152

PMID

Disease

PubChem Disease

MedGen Diseases

Fucosyltransferase 6 deficiency

OMIM Phenotypes

FUCOSYLTRANSFERASE 6 DEFICIENCY

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	173958	WB:WBGene00006402
Caenorhabditis elegans	187342	WB:WBGene00001507
Drosophila melanogaster	39653	FB:FBgn0036485
Xenopus laevis	399049	Xenbase:XB-GENE-6037639
Xenopus laevis	100337596	Xenbase:XB-GENE-5772172
Xenopus tropicalis	100495376	Xenbase:XB-GENE-6037628

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements