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G00052MO

Summary

GlyTouCan ID: G00052MO
IUPAC Condensed: Fuc(a1-2)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-
Motifs: Blood group H (type 2) Leb Lewis b Ley
Subsumption Level: Fully-defined saccharide
Monoisotopic Mass: 675.26

External Links

GlyGen

G00052MO

ChEBI

59045

PubChem Compound

45266908

PubChem Substance

252284113

3D Structures

GlycoNAVI: G00052MO
GLYCAM: LFucpa1-2DGalpb1-4[LFucpa1-3]DGlcpNAcb1-OH

GlycoShape

G00052MO

Displaying 1 entry
Archetype	α	β
G04690JX	G82236PZ	G00052MO

Organisms

Displaying entries **1 - 5** of 15 in total

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Organisms	Evidence
Felis catus (domestic cat)	GlyTouCan(glycome-db)
Mus musculus (house mouse)	GlyTouCan(glycome-db)
Helicobacter pylori 26695	GlyTouCan(bcsdb) GlyTouCan(glycome-db)
Bos taurus (domestic cattle)	GlyTouCan(glycome-db)
Rattus	GlyTouCan(glycome-db)

Taxonomic Hierarchy

root

Viruses [inference]

Riboviria [inference]

Pararnavirae [inference]

Artverviricota [inference]

Revtraviricetes [inference]

Ortervirales [inference]

Retroviridae [inference]

Orthoretrovirinae [inference]

Lentivirus [inference]

Primate lentivirus group [inference]

unclassified Primate lentivirus group [inference]

Human immunodeficiency virus

Human immunodeficiency virus 1

cellular organisms [inference]

Bacteria (eubacteria) [inference]

Campylobacterota [inference]

Epsilonproteobacteria [inference]

Campylobacterales [inference]

Helicobacteraceae [inference]

Helicobacter [inference]

Helicobacter pylori

Eukaryota (eucaryotes) [inference]

Opisthokonta [inference]

Metazoa (metazoans) [inference]

Eumetazoa [inference]

Bilateria [inference]

Deuterostomia [inference]

Chordata (chordates) [inference]

Craniata [inference]

Vertebrata (vertebrates) [inference]

Gnathostomata (jawed vertebrates) [inference]

Teleostomi [inference]

Euteleostomi (bony vertebrates) [inference]

Sarcopterygii [inference]

Dipnotetrapodomorpha [inference]

Tetrapoda (tetrapods) [inference]

Amniota (amniotes) [inference]

Mammalia (mammals) [inference]

Theria [inference]

Eutheria (placentals) [inference]

Boreoeutheria [inference]

Laurasiatheria [inference]

Artiodactyla (even-toed ungulates & whales) [inference]

Suina [inference]

Suidae (pigs) [inference]

Sus [inference]

Sus scrofa (pig)

Ruminantia [inference]

Pecora [inference]

Bovidae [inference]

Bovinae [inference]

Bos (cattle) [inference]

Bos taurus (domestic cattle)

Carnivora (carnivores) [inference]

Caniformia [inference]

Canidae (dog, coyote, wolf, fox) [inference]

Canis [inference]

Canis lupus (gray wolf) [inference]

Canis lupus familiaris (dog)

Feliformia [inference]

Felidae (cat family) [inference]

Felinae [inference]

Felis [inference]

Felis catus (domestic cat)

Euarchontoglires [inference]

Glires (Rodents and rabbits) [inference]

Lagomorpha [inference]

Leporidae (rabbits and hares) [inference]

Oryctolagus [inference]

Oryctolagus cuniculus (rabbit)

Rodentia (rodent) [inference]

Myomorpha (mice and others) [inference]

Muroidea [inference]

Muridae [inference]

Murinae [inference]

Rattus

Mus (mice) [inference]

Mus [inference]

Mus musculus (house mouse)

Cricetidae [inference]

Cricetinae (hamsters) [inference]

Mesocricetus [inference]

Mesocricetus auratus (golden hamster)

Primates [inference]

Haplorrhini [inference]

Simiiformes [inference]

Catarrhini [inference]

Cercopithecoidea [inference]

Cercopithecidae (Old World monkeys) [inference]

Cercopithecinae [inference]

Chlorocebus [inference]

Chlorocebus aethiops (grivet)

Hominoidea (apes) [inference]

Hominidae (great apes) [inference]

Homininae [inference]

Homo [inference]

Homo sapiens (human)

GlycoGene Database (GGDB)

Displaying **all 2** entries
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
FUT3	GDP-Fuc	G61459JW	R	G00052MO	R	7721776
FUT5	GDP-Fuc	G61459JW	R	G00052MO	R	16484342

Displaying **all 5** entries
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
FUT5	GDP-Fuc	G61459JW	(CH2)8COOCH3	G00052MO	(CH2)8COOCH3	9079712
FUT3	GDP-Fuc	G61459JW	R	G00052MO	R	7721776
FUT5	GDP-Fuc	G61459JW	R	G00052MO	R	16484342
FUT3	GDP-Fuc	G61459JW	(CH2)8COOCH3	G00052MO	(CH2)8COOCH3	9079712
FUT6	GDP-Fuc	G61459JW	(CH2)8COOCH3	G00052MO	(CH2)8COOCH3	9079712

GlycoEpitope

Epitope ID: EP0018

Sequence Descriptors

GlycoCT

RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:a-lgal-HEX-1:5|6:d
4b:b-dgal-HEX-1:5
5b:a-lgal-HEX-1:5|6:d
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:1o(4+1)4d
4:4o(2+1)5d

WURCS

WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5][a2112h-1b_1-5]/1-2-3-2/a3-b1_a4-c1_c2-d1

Literature

Displaying entries **1 - 10** of **410** in total

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PubMed ID	Title	First Author	Publication Date	Source
37202521	Structural basis for Lewis antigen synthesis by the α1,3-fucosyltransferase FUT9	Kadirvelraj R	2023 May 18	PubChem
36932748	X-ray inhibits FUT4-mediated proliferation in A549 cells by downregulating SP1 expression	Liang JX	2023 Mar 04	PubChem
34571111	Partners in crime: The Lewis Y antigen and fucosyltransferase IV in Helicobacter pylori-induced gastric cancer	Aziz F	2022 Apr	PubChem
33813387	Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling	Hotta H	2021 Apr	PubChem
32536918	Lipo-Based Vaccines as an Approach to Target Dendritic Cells for Induction of T- and iNKT Cell Responses	Stolk DA	2020 May 27	PubChem
32757229	Blood group‐related antigen <scp>Ley</scp> on human platelets and its involvement in platelet aggregation via a possible interaction with <scp>CD61</scp>	Zhu H	2020 Aug 05	PubChem
31565939	Synthesis of Lewis Y Analogues and Their Protein Conjugates for Structure–Immunogenicity Relationship Studies of Lewis Y Antigen	Li Q	2019 Sep 30	PubChem
30869134	Human adenovirus type 5 increases host cell fucosylation and modifies Ley antigen expression	Gutiérrez-Huante K	2019 Mar 31	PubChem
30841890	Upregulation of MUC5AC production and deposition of LEWIS determinants by HELICOBACTER PYLORI facilitate gastric tissue colonization and the maintenance of infection	Gonciarz W	2019 Mar 06	PubChem
30816446	Co‑expression of Lewis�y antigen and CD147 in�epithelial ovarian cancer is correlated with malignant progression and poor prognosis	Liu J	2019 Feb 20	PubChem

PubAnnotation

Displaying entries **1 - 5** of 9 in total

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Title	Authors	Source	Publication Date	PubMed ID
Synthesis of type 2 Lewis antigens via novel regioselective glycosylation of an orthogonally protected lactosamine diol derivative.	Yamazaki Y Sezukuri K Takada J Obata H Kimura S Ohmae M	Carbohydr Res	2016 Mar 3	26851536
Studies on the synthesis of Lewis-y oligosaccharides.	Mandal PK Turnbull WB	Carbohydr Res	2011 Oct 18	21851931
Glycomimicry: display of fucosylation on the lipo-oligosaccharide of recombinant Escherichia coli K12.	Yavuz E Maffioli C Ilg K Aebi M Priem B	Glycoconj J	2011 Jan	21286806
Norwalk virus-like particles bind specifically to A, H and difucosylated Lewis but not to B histo-blood group active glycosphingolipids.	Nilsson J Rydell GE Le Pendu J Larson G	Glycoconj J	2009 Dec	19387828
NMR study on the hydroxy protons of the Lewis X and Lewis Y oligosaccharides.	Bekiroglu S Kenne L Sandström C	Carbohydr Res	2004 Oct 4	15388363

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GlycoEpitope

Sequence Descriptors

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Acknowledgements