G00052MO

Summary
GlyTouCan ID
G00052MO
IUPAC Condensed
Fuc(a1-2)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-
Motifs
Blood group H (type 2) Leb Lewis b Ley
Subsumption Level
Fully-defined saccharide
Monoisotopic Mass
675.26
3D Structures
GlycoShape
G00052MO
Displaying 1 entry
Archetype α β
G04690JX
G82236PZ
G00052MO
Organisms
Taxonomic Hierarchy
GlycoGene Database (GGDB)
Displaying all 2 entries
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
FUT5 GDP-Fuc
G61459JW
R
G00052MO
R
FUT3 GDP-Fuc
G61459JW
R
G00052MO
R
Displaying all 5 entries
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
FUT5 GDP-Fuc
G61459JW
R
G00052MO
R
FUT5 GDP-Fuc
G61459JW
(CH2)8COOCH3
G00052MO
(CH2)8COOCH3
FUT3 GDP-Fuc
G61459JW
R
G00052MO
R
FUT3 GDP-Fuc
G61459JW
(CH2)8COOCH3
G00052MO
(CH2)8COOCH3
FUT6 GDP-Fuc
G61459JW
(CH2)8COOCH3
G00052MO
(CH2)8COOCH3
GlycoEpitope
Epitope ID
EP0018
Sequence Descriptors
GlycoCT
RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:a-lgal-HEX-1:5|6:d
4b:b-dgal-HEX-1:5
5b:a-lgal-HEX-1:5|6:d
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:1o(4+1)4d
4:4o(2+1)5d
WURCS
WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5][a2112h-1b_1-5]/1-2-3-2/a3-b1_a4-c1_c2-d1
Literature
Displaying entries 31 - 40 of 410 in total
PubMed ID Title First Author Publication Date Source
26437978 Screening of enzymatic synthesis and expression of Lewis determinants in human colorectal carcinoma Fernández-Briera A 2015 Oct
  • PubChem
25757815 Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies Dingjan T 2015 Oct
  • PubChem
25735572 Regulatory function of β1,4-galactosyltransferase I expression on Lewis-Y glycan and embryo implantation Gu J 2015 May 15
  • PubChem
25799278 Lewisy Promotes Migration of Oral Cancer Cells by Glycosylation of Epidermal Growth Factor Receptor Lin W 2015 Mar 23
  • PubChem
25726913 Lewis y enhances CAM-DR in ovarian cancer cells by activating the FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression Yan L 2015 Jun
  • PubChem
25672851 Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression Shan X 2015 Feb 10
  • PubChem
26026738 A phase II trial with anti-Lewis-Y monoclonal antibody (hu3S193) for the treatment of platinum resistant/refractory ovarian, fallopian tube and primary peritoneal carcinoma Smaletz O 2015 Aug
  • PubChem
26169734 Antibody-Carbohydrate Recognition from Docked Ensembles Using the AutoMap Procedure Dingjan T 2015
  • PubChem
24998328 Overexpression of Lewis y antigen promotes human epididymis protein 4-mediated invasion and metastasis of ovarian cancer cells Zhuang H 2014 Oct
  • PubChem
25416440 The expression of annexin II and Lewis y antigen in ovarian epithelial tumors and the correlation between them Zhuang H 2014 Nov 22
  • PubChem

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 8, 2025