G00052MO
| Organisms | Evidence |
|---|---|
| Oryctolagus cuniculus (rabbit) | |
| Chlorocebus aethiops (grivet) | |
| Felis catus (domestic cat) | |
| Helicobacter pylori | |
| Mus musculus (house mouse) |
| Gene Symbol | Donor | Acceptor | Reducing terminal(Acceptor) | Product | Reducing terminal(Product) | Reference |
|---|---|---|---|---|---|---|
| FUT5 | GDP-Fuc |
|
R |
|
R | |
| FUT5 | GDP-Fuc |
|
(CH2)8COOCH3 |
|
(CH2)8COOCH3 | |
| FUT3 | GDP-Fuc |
|
R |
|
R | |
| FUT3 | GDP-Fuc |
|
(CH2)8COOCH3 |
|
(CH2)8COOCH3 | |
| FUT6 | GDP-Fuc |
|
(CH2)8COOCH3 |
|
(CH2)8COOCH3 |
RES 1b:b-dglc-HEX-1:5 2s:n-acetyl 3b:a-lgal-HEX-1:5|6:d 4b:b-dgal-HEX-1:5 5b:a-lgal-HEX-1:5|6:d LIN 1:1d(2+1)2n 2:1o(3+1)3d 3:1o(4+1)4d 4:4o(2+1)5d
| PubMed ID | Title | First Author | Publication Date | Source |
|---|---|---|---|---|
| 26437978 | Screening of enzymatic synthesis and expression of Lewis determinants in human colorectal carcinoma | Fernández-Briera A | 2015 Oct |
|
| 25757815 | Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies | Dingjan T | 2015 Oct |
|
| 25735572 | Regulatory function of β1,4-galactosyltransferase I expression on Lewis-Y glycan and embryo implantation | Gu J | 2015 May 15 |
|
| 25799278 | Lewisy Promotes Migration of Oral Cancer Cells by Glycosylation of Epidermal Growth Factor Receptor | Lin W | 2015 Mar 23 |
|
| 25726913 | Lewis y enhances CAM-DR in ovarian cancer cells by activating the FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression | Yan L | 2015 Jun |
|
| 25672851 | Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression | Shan X | 2015 Feb 10 |
|
| 26026738 | A phase II trial with anti-Lewis-Y monoclonal antibody (hu3S193) for the treatment of platinum resistant/refractory ovarian, fallopian tube and primary peritoneal carcinoma | Smaletz O | 2015 Aug |
|
| 26169734 | Antibody-Carbohydrate Recognition from Docked Ensembles Using the AutoMap Procedure | Dingjan T | 2015 |
|
| 24998328 | Overexpression of Lewis y antigen promotes human epididymis protein 4-mediated invasion and metastasis of ovarian cancer cells | Zhuang H | 2014 Oct |
|
| 25416440 | The expression of annexin II and Lewis y antigen in ovarian epithelial tumors and the correlation between them | Zhuang H | 2014 Nov 22 |
|
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Supported by JST NBDC Grant Number JPMJND2204
Partly supported by NIH Common Fund Grant #1U01GM125267-01
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Last updated: December 8, 2025