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Guidelines

MIRAGE

alkaline phosphatase, biomineralization associated

Summary

Gene Symbol

Alpl

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25586

KEGG Gene ID

PubChem

25586

Alliance of Genome Resources

RGD:2100

Annotation

Keyword

Biomineralization
Calcium
Cell membrane
Direct protein sequencing
Disulfide bond
GPI-anchor
Hydrolase
Magnesium
Metal-binding
Mitochondrion
Phosphoprotein
Reference proteome
Signal
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P08289	Alkaline phosphatase liver/bone/kidney isozyme Phosphoamidase Phosphocreatine phosphatase
A6ITE7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
endochondral ossification	ISO
developmental process involved in reproduction	ISO
cellular homeostasis
bone mineralization	ISS
bone mineralization	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process [inference]

pyridoxal 5'-phosphate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

pyridoxal 5'-phosphate metabolic process

organophosphate metabolic process [inference]

pyridoxal 5'-phosphate metabolic process

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal 5'-phosphate metabolic process

futile creatine cycle

reproductive process [inference]

developmental process involved in reproduction

multicellular organismal process [inference]

ossification [inference]

replacement ossification [inference]

endochondral ossification

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

developmental process [inference]

developmental process involved in reproduction

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

tooth mineralization [inference]

cementum mineralization

homeostatic process [inference]

cellular homeostasis

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to antibiotic

response to peptide [inference]

response to cytokine [inference]

response to macrophage colony-stimulating factor

response to nitrogen compound [inference]

response to vitamin B6

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide hormone [inference]

response to insulin

response to salt [inference]

response to sodium phosphate

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
extracellular region	IDA
obsolete extracellular space
mitochondrial intermembrane space	ISS
mitochondrial intermembrane space	ISO
mitochondrial intermembrane space	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

organelle membrane [inference]

mitochondrial membrane

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

extracellular membrane-bounded organelle

extracellular organelle [inference]

extracellular membrane-bounded organelle

side of membrane

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	PMID
alkaline phosphatase activity	ISO
alkaline phosphatase activity	TAS
alkaline phosphatase activity	IDA
alkaline phosphatase activity	IBA
alkaline phosphatase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity

inorganic diphosphate phosphatase activity

nucleoside diphosphate phosphatase activity [inference]

ADP phosphatase activity

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

hydrolase activity, acting on phosphorus-nitrogen bonds [inference]

phosphoamidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alkaline phosphatase

Functional Category

I: Lipid transport and metabolism
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 4** entries
Gene Ontology
alkaline phosphatase activity
dephosphorylation
hydrolase activity
metal ion binding

Displaying **all 3** entries
InterPro
Alkaline phosphatase, active site
Alkaline phosphatase
Alkaline-phosphatase-like, core domain superfamily

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:19697513

Rhea

H₂O + N-phosphocreatine

phosphate + creatine

Enzyme

3.9.1.1

PMID

H₂O + a phosphate monoester

an alcohol + phosphate

Enzyme

PMID

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11647	MGI:87983
Homo sapiens	249	HGNC:438
Saccharomyces cerevisiae S288C	852092	SGD:S000002889

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Last updated: April 6, 2026