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ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

Summary

Gene Symbol

ST6GALNAC3

Aliases

ST6GALNAC III

Organism

Homo sapiens (human)

External Links

NCBI Gene

256435

GGDB ID

gg058

HGNC

19343

mRNA

NM_152996

map

1p31.1

Protein

NP_694541

OMIM

610133

KEGG Gene ID

hsa:256435

PubChem

256435

Alliance of Genome Resources

HGNC:19343

JoGo

ST6GALNAC3

TogoVar

ST6GALNAC3

Annotation

Keyword

Alternative splicing
Disulfide bond
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Proteomics identification
Reference proteome
Sialic acid
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DM98
Q8NDV1	GalNAc alpha-2,6-sialyltransferase III ST6GalNAc III STY Sialyltransferase 7C

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
ganglioside biosynthetic process	IBA
lipid metabolic process
glycolipid metabolic process	IEA
glycosylceramide metabolic process	IDA
glycosphingolipid metabolic process	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process

glycoprotein biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process

lipid metabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosylceramide metabolic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

glycosphingolipid metabolic process

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosylceramide metabolic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

ganglioside biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process

glycosphingolipid metabolic process

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosylceramide metabolic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process

glycoprotein biosynthetic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process

glycosphingolipid metabolic process

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosylceramide metabolic process

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

ganglioside biosynthetic process

viral process [inference]

viral protein processing

Displaying **all 3** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
Golgi membrane	IEA
nucleoplasm

GO Hierarchy

cellular component

cellular anatomical structure [inference]

nucleoplasm

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	TAS
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA
protein binding	IPI
sialyltransferase activity	TAS
sialyltransferase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sialyltransferase

Functional Category

H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
ganglioside biosynthetic process
lipid metabolic process
sialyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
GT29-like superfamiliy
Glycosyl transferase family 29

GlycoGene Database (GGDB)

GGDB ID

gg058

Gene Symbol

ST6GALNAC3

Reactions

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
CMP-Neu5Ac	G03277YI	Cer	G45714BQ	Cer	10207017
CMP-Neu5Ac	G65562ZE	Ser/Thr	G01614ZM	Ser/Thr	16169874

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
CMP-Neu5Ac	G03277YI	Cer	G45714BQ	Cer	10207017
CMP-Neu5Ac	G65562ZE	Ser/Thr	G01614ZM	Ser/Thr	10536037 16169874

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Reference
CMP-Neu5Ac	G00031MO	Ser/Thr	10536037
CMP-Neu5Ac	G57321FI	Ser/Thr	10536037

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Mus musculus	NP_035502	NM_011372
Rattus norvegicus	NP_061996	NM_019123

KEGG BRITE Database

Orthology

K03373

Name

N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7C) [EC:2.4.3.7]

References

10207017

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05914	2.4.3.3 2.4.3.7	G65562ZE	G01614ZM
R05959	2.4.3.7	G03277YI	G45714BQ

Rhea

RHEA:53896

an α-Neu5Ac-(2→3)-β-D-Gal-(1→3)-D-GlcNAc derivative + CMP-N-acetyl-β-neuraminate

an α-Neu5Ac-(2→3)-β-D-Gal-(1→3)-[α-Neu5Ac-(2→6)]-D-GlcNAc-R + H⁺ + CMP

Enzyme

2.4.3.7

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP005046
Gene Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	20447	MGI:1341828
Rattus norvegicus	29758	RGD:3677
Danio rerio	322609	ZFIN:ZDB-GENE-030131-1329
Xenopus laevis	108714200	Xenbase:XB-GENE-17341894
Xenopus tropicalis	100495364	Xenbase:XB-GENE-987935

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements