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serine (or cysteine) peptidase inhibitor, clade A, member 5

Summary

Gene Symbol

Serpina5

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

268591

KEGG Gene ID

PubChem

268591

Alliance of Genome Resources

MGI:107817

Annotation

Keyword

Glycoprotein
Reference proteome
Secreted
Serine protease inhibitor
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P70458	Plasminogen activator inhibitor 3 Protein C inhibitor Serpin A5
Q8BVN1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
spermatogenesis	IMP
negative regulation of proteolysis	ISO
seminal clot liquefaction	ISO
seminal clot liquefaction	IEA

GO Hierarchy

biological process

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

seminal clot liquefaction

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

Displaying entries **6 - 10** of 52 in total

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GO Term	Evidence Code	PMID
extracellular region	IBA
extracellular region	IEA
obsolete extracellular space
external side of plasma membrane	ISO
external side of plasma membrane	IEA

GO Hierarchy

cellular component

protein-containing complex

peptidase inhibitor complex [inference]

protease inhibitor complex [inference]

serine protease inhibitor complex [inference]

cellular anatomical structure [inference]

extracellular region

membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

acrosomal membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

acrosomal membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

platelet dense tubular network

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

platelet dense tubular network

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
retinoic acid binding	ISS
retinoic acid binding	ISO
retinoic acid binding	IEA
protease binding	ISO
protease binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylcholine binding

isoprenoid binding [inference]

retinoid binding [inference]

retinoic acid binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

cation binding [inference]

phosphatidylcholine binding

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

quaternary ammonium group binding [inference]

phosphatidylcholine binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	179195	WB:WBGene00005648
Drosophila melanogaster	34091	FB:FBgn0031973
Homo sapiens	5104	HGNC:8723

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026

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