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apolipoprotein C2

Summary

Gene Symbol

APOC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

344

KEGG Gene ID

PubChem

344

Alliance of Genome Resources

HGNC:609

Annotation

Keyword

3D-structure
Chylomicron
Direct protein sequencing
Disease variant
HDL
Hyperlipidemia
LDL
Lipid degradation
Lipid transport
Lipoprotein
Proteomics identification
Reference proteome
Secreted
Sialic acid
Signal
VLDL

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A024R0T9	Apolipoprotein C2
P02655	Apolipoprotein C2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
lipid metabolic process	IEA
lipid transport	IEA
positive regulation of triglyceride catabolic process	IDA
positive regulation of very-low-density lipoprotein particle remodeling	IDA
negative regulation of very-low-density lipoprotein particle clearance	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipid catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

lipoprotein catabolic process

primary metabolic process [inference]

lipid metabolic process

lipid catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

lipoprotein catabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling

multicellular organismal process [inference]

plasma lipoprotein particle clearance [inference]

high-density lipoprotein particle clearance

triglyceride-rich lipoprotein particle clearance [inference]

chylomicron remnant clearance

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport

phospholipid transport [inference]

phospholipid efflux

sterol transport [inference]

cholesterol transport [inference]

organophosphate ester transport [inference]

phospholipid transport [inference]

phospholipid efflux

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport

regulation of cholesterol transport [inference]

negative regulation of cholesterol transport

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis

regulation of lipid localization [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport

regulation of cholesterol transport [inference]

negative regulation of cholesterol transport

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of cellular component organization [inference]

positive regulation of very-low-density lipoprotein particle remodeling

positive regulation of multicellular organismal process [inference]

positive regulation of very-low-density lipoprotein particle remodeling

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of lipid catabolic process [inference]

regulation of lipid catabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid catabolic process [inference]

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process

regulation of ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process

regulation of small molecule metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process

negative regulation of lipid metabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process

regulation of lipid catabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid catabolic process [inference]

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of fatty acid metabolic process [inference]

positive regulation of fatty acid biosynthetic process

positive regulation of cellular component organization [inference]

positive regulation of very-low-density lipoprotein particle remodeling

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

regulation of cellular component organization [inference]

regulation of very-low-density lipoprotein particle remodeling [inference]

positive regulation of very-low-density lipoprotein particle remodeling

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

positive regulation of cellular component organization [inference]

positive regulation of very-low-density lipoprotein particle remodeling

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis

regulation of multicellular organismal process [inference]

regulation of very-low-density lipoprotein particle remodeling [inference]

positive regulation of very-low-density lipoprotein particle remodeling

regulation of lipoprotein particle clearance [inference]

regulation of very-low-density lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

positive regulation of multicellular organismal process [inference]

positive regulation of very-low-density lipoprotein particle remodeling

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
extracellular region	EXP
extracellular region	NAS
extracellular region	TAS
extracellular region	IDA
extracellular region	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

low-density lipoprotein particle

high-density lipoprotein particle

spherical high-density lipoprotein particle

triglyceride-rich plasma lipoprotein particle [inference]

chylomicron

extracellular protein-containing complex [inference]

plasma lipoprotein particle [inference]

low-density lipoprotein particle

high-density lipoprotein particle

spherical high-density lipoprotein particle

triglyceride-rich plasma lipoprotein particle [inference]

chylomicron

cellular anatomical structure [inference]

extracellular region

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
enzyme activator activity	IEA
lipid binding	IDA
phospholipase activator activity	IDA
phospholipase activator activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

phospholipase binding

identical protein binding

lipid binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

lipase inhibitor activity

enzyme activator activity

lipase activator activity [inference]

molecular function activator activity

enzyme activator activity

lipase activator activity [inference]

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

lipase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Apolipoprotein C-II

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
chylomicron remnant clearance
high-density lipoprotein particle clearance
lipid binding
lipid metabolic process
lipid transport
lipoprotein lipase activator activity
negative regulation of very-low-density lipoprotein particle clearance
phospholipase activator activity
phospholipase binding
positive regulation of phospholipid catabolic process

Displaying **all 2** entries
InterPro
ApoC-II domain superfamily
Apolipoprotein C-II

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0111418	familial apolipoprotein C-II deficiency	Alliance of Genome Resources
DOID:1168	familial hyperlipidemia	Alliance of Genome Resources
DOID:2377	multiple sclerosis	Alliance of Genome Resources

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OrthoDB (Group)

International Collaboration

Acknowledgements