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Guidelines

MIRAGE

insulin like growth factor binding protein 3

Summary

Gene Symbol

IGFBP3

Organism

Homo sapiens (human)

External Links

NCBI Gene

3486

KEGG Gene ID

PubChem

3486

Alliance of Genome Resources

HGNC:5472

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor binding
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P17936
B3KPF0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
MAPK cascade
regulation of cell growth
osteoblast differentiation	IEA
negative regulation of protein phosphorylation	IDA
protein phosphorylation	IDA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

MAPK cascade

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cell death [inference]

programmed cell death [inference]

apoptotic process

cell population proliferation [inference]

epithelial cell proliferation [inference]

type B pancreatic cell proliferation

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction

regulation of insulin-like growth factor receptor signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signaling [inference]

negative regulation of signal transduction

regulation of growth [inference]

regulation of cell growth

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of smooth muscle cell proliferation

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction

regulation of insulin-like growth factor receptor signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of myoblast differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

MAPK cascade

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction

regulation of insulin-like growth factor receptor signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of myoblast differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of smooth muscle cell proliferation

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

regulation of cellular component organization [inference]

regulation of cell growth

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
obsolete extracellular space
nucleus	EXP
nucleus	IDA
nucleus	IEA
endoplasmic reticulum lumen	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

growth factor complex [inference]

insulin-like growth factor binding protein complex

insulin-like growth factor ternary complex

extracellular protein-containing complex [inference]

insulin-like growth factor binding protein complex

insulin-like growth factor ternary complex

cellular anatomical structure [inference]

extracellular region

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
fibronectin binding	IBA
fibronectin binding	IEA
protein binding	IPI
insulin-like growth factor binding	NAS
insulin-like growth factor binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

fibronectin binding

growth factor binding [inference]

insulin-like growth factor binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

phosphatase regulator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

protein phosphatase regulator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050589	inflammatory bowel disease	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:3491	Turner syndrome	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:2671	transitional cell carcinoma	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	16009	MGI:96438
Rattus norvegicus	24484	RGD:2874

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Last updated: April 6, 2026