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GALAXY
MCAW
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GRable
Guidelines
MIRAGE
amyloid beta precursor protein
Summary
- Gene Symbol
-
- APP
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Alzheimer disease
- Amyloid
- Amyloidosis
- Apoptosis
- Cell adhesion
- Cell membrane
- Cell projection
- Coated pit
- Coiled coil
- Copper
- Cytoplasm
- Cytoplasmic vesicle
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Endocytosis
- Endoplasmic reticulum
- Endosome
- Golgi apparatus
- Heparin-binding
- Iron
- Isopeptide bond
- Metal-binding
- Neurodegeneration
- Notch signaling pathway
- Nucleus
- Oxidation
- Phosphoprotein
- Protease
- Proteoglycan
- Proteomics identification
- Reference proteome
- Secreted
- Serine protease inhibitor
- Signal
- Sulfation
- Transmembrane helix
- Ubl conjugation
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| E9PG40 |
|
| P05067 |
|
| A0A140VJC8 |
|
| B4DGD0 |
|
| B4DJT9 |
|
| A0A0A0MRG2 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of transcription by RNA polymerase II |
|
|
| regulation of translation |
|
|
| proteolysis |
|
|
| calcium ion transport |
|
|
| intracellular copper ion homeostasis |
|
GO Hierarchy
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of nitric oxide biosynthetic process
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of cell activation
- positive regulation of response to endoplasmic reticulum stress
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of response to endoplasmic reticulum stress
- positive regulation of long-term synaptic depression
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of response to endoplasmic reticulum stress
- regulation of response to calcium ion
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of nitric oxide biosynthetic process
- negative regulation of gene expression
- positive regulation of nitric oxide biosynthetic process
- negative regulation of gene expression
- positive regulation of nitric oxide biosynthetic process
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of Toll signaling pathway
- positive regulation of excitatory postsynaptic potential
- positive regulation of cell activation
- positive regulation of response to endoplasmic reticulum stress
- regulation of multicellular organism growth
- regulation of amyloid-beta clearance
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
positive regulation of signaling [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
regulation of trans-synaptic signaling [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of signaling [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
positive regulation of cellular process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of macromolecule metabolic process
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
positive regulation of response to stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
positive regulation of response to stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
regulation of response to stress [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
regulation of trans-synaptic signaling [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression
regulation of cytokine production [inference]
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
regulation of RNA biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of macromolecule metabolic process
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
regulation of catabolic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression
regulation of cytokine production [inference]
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
regulation of RNA biosynthetic process [inference]
positive regulation of macromolecule metabolic process
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
regulation of protein metabolic process
regulation of RNA metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process
regulation of programmed cell death [inference]
positive regulation of cellular process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of macromolecule metabolic process
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
positive regulation of intracellular signal transduction [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cellular response to stress [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
positive regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region |
|
|
| extracellular region |
|
|
| extracellular region |
|
|
| extracellular region |
|
|
| extracellular region |
|
GO Hierarchy
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080348 | Alzheimer's disease 1 | |
| DOID:0081292 | traumatic brain injury | |
| DOID:1561 | cognitive disorder | |
| DOID:0070028 | APP-related cerebral amyloid angiopathy | |
| DOID:10652 | Alzheimer's disease |
Ortholog
| Species | Gene ID | Alliance of Genome Resources |
|---|---|---|
| 11820 | MGI:88059 | |
| 54226 | RGD:2139 | |
| 180783 | WB:WBGene00000149 | |
| 31002 | FB:FBgn0000108 |
