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unc-13 homolog A

Summary

Gene Symbol

Unc13a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

382018

PubChem

382018

Alliance of Genome Resources

MGI:3051532

Annotation

Keyword

3D-structure
Calcium
Cell membrane
Cell projection
Coiled coil
Cytoplasm
Differentiation
Exocytosis
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Synapse
Zinc
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q4KUS2	Munc13-1
H3BJZ7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
positive regulation of neurotransmitter secretion	IMP	11792326
neurotransmitter secretion	ISS
neurotransmitter secretion	ISO
neurotransmitter secretion	IMP	11792326
neuromuscular junction development	IGI	15988013

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

organic substance metabolic process [inference]

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

calcium-ion regulated exocytosis [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis

membrane docking [inference]

organelle localization by membrane tethering [inference]

vesicle docking [inference]

vesicle docking involved in exocytosis [inference]

cellular developmental process [inference]

cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

synaptic vesicle maturation

cellular component assembly [inference]

protein-containing complex assembly [inference]

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

exocytic process [inference]

vesicle docking involved in exocytosis [inference]

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

calcium-ion regulated exocytosis [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

signal release [inference]

signal release from synapse [inference]

multicellular organismal process [inference]

innervation

developmental process [inference]

developmental maturation [inference]

synaptic vesicle maturation

cellular developmental process [inference]

cell differentiation

localization [inference]

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

calcium-ion regulated exocytosis [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

calcium-ion regulated exocytosis [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

signal release [inference]

signal release from synapse [inference]

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

calcium-ion regulated exocytosis [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

signal release [inference]

signal release from synapse [inference]

establishment of localization in cell [inference]

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

organelle localization [inference]

vesicle localization [inference]

secretory granule localization [inference]

dense core granule localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

organelle localization by membrane tethering [inference]

vesicle docking [inference]

vesicle docking involved in exocytosis [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of amyloid precursor protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of amyloid precursor protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of amyloid precursor protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of glutamate receptor signaling pathway

regulation of glutamate receptor signaling pathway [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

regulation of synaptic plasticity [inference]

positive regulation of synaptic plasticity

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of synaptic transmission [inference]

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of synaptic transmission [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of glutamate receptor signaling pathway

regulation of glutamate receptor signaling pathway [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of glutamate receptor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of glutamate receptor signaling pathway

regulation of glutamate receptor signaling pathway [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

regulation of synaptic plasticity [inference]

positive regulation of synaptic plasticity

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of synaptic vesicle priming

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of synaptic transmission [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of protein-containing complex assembly [inference]

regulation of synaptic vesicle priming

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

positive regulation of synaptic plasticity

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

long-term synaptic potentiation

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA
Golgi-associated vesicle	ISO
plasma membrane	IBA
axon	IDA	23791195
synaptic vesicle membrane	IBA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

cytoplasm

cell cortex [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

cytoplasmic region [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane

presynaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle

neuron projection terminus [inference]

axon terminus [inference]

calyx of Held

presynaptic active zone

presynapse

terminal bouton

axon terminus [inference]

calyx of Held

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
SNARE binding	ISO
calcium ion binding	IEA
protein binding	IPI	10488064 19812333 19996097
calmodulin binding	ISO
calmodulin binding	IDA	31787876

GO Hierarchy

syntaxin-1 binding

calmodulin binding

cytoskeletal protein binding [inference]

spectrin binding

lipid binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding

spectrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

unc-13

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 14 in total

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Gene Ontology
calcium ion binding
calmodulin binding
chemical synaptic transmission
dense core granule priming
diacylglycerol binding
metal ion binding
neuromuscular junction development
phospholipid binding
presynaptic dense core vesicle exocytosis
synaptic transmission, glutamatergic

Displaying **all 4** entries
InterPro
C2 domain superfamily
C2 domain
MUN domain
Protein Unc-13

Ortholog

Displaying entries **1 - 10** of 44 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	10497	FB:FBgn0025726
Homo sapiens	23025	Xenbase:XB-GENE-6039664	HUMAN41826
Rattus norvegicus	64829		RATNO10934
Xenopus tropicalis	382018	Xenbase:XB-GENE-6039664
Pan troglodytes	455844		PANTR17586
Danio rerio	568618		DANRE22601
Macaca mulatta	720000		MACMU18595
Equus caballus	100146356		HORSE19841
Ciona intestinalis	100176945		CIOIN05888
Callithrix jacchus	100411765		CALJA23933

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements