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LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Summary

Gene Symbol

LFNG

Aliases

SCDO3

Organism

Homo sapiens (human)

External Links

NCBI Gene

3955

GGDB ID

gg133

HGNC

6560

mRNA

XM_166539

map

7p22

Protein

Q8NES3

OMIM

602576

KEGG Gene ID

hsa:3955

PubChem

3955

Alliance of Genome Resources

HGNC:6560

JoGo

LFNG

TogoVar

LFNG

Annotation

Keyword

Alternative splicing
Developmental protein
Disease variant
Disulfide bond
Dwarfism
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8NES3	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 18 in total

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GO Term	Evidence Code	PMID
regulation of somitogenesis	IMP
T cell differentiation	ISS
T cell differentiation	IEA
negative regulation of Notch signaling pathway	ISS
negative regulation of Notch signaling pathway	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

T cell differentiation

T cell activation [inference]

T cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

T cell differentiation

T cell activation [inference]

T cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

T cell differentiation

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

T cell differentiation

T cell activation [inference]

T cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

pattern specification process

regionalization [inference]

anterior/posterior pattern specification [inference]

segmentation [inference]

somitogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

anatomical structure formation involved in morphogenesis [inference]

somitogenesis

anatomical structure development [inference]

ovarian follicle development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

T cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of reproductive process [inference]

positive regulation of meiotic cell cycle

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of somitogenesis

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of cell cycle [inference]

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle

regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle

regulation of multicellular organismal process [inference]

regulation of somitogenesis

regulation of reproductive process [inference]

regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle

positive regulation of reproductive process [inference]

positive regulation of meiotic cell cycle

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
Golgi membrane	IEA
extracellular region	NAS
Golgi apparatus	IEA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
glycosyltransferase activity	IEA
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	ISS
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	TAS
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IDA
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

beta-1,3-n-acetylglucosaminyltransferase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
regulation of Notch signaling pathway
transferase activity

Displaying 1 entry
InterPro
Fringe-like, glycosyltransferase domain

Human Protein Atlas

ENSG00000106003

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg133

Gene Symbol

LFNG

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G96881BQ	-O-EGF	G26238GL	-O-EGF	10935626

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G96881BQ	-O-EGF	G26238GL	-O-EGF	10935626
UDP-GlcNAc	G96881BQ	[alpha]-pNp	G26238GL	[alpha]-pNp	10935626

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Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-Gal	G96881BQ	[alpha]-pNp	10935626
UDP-GalNAc	G96881BQ	-O-EGF	10935626
UDP-Glc	G96881BQ	[alpha]-pNp	10935626
UDP-GlcNAc	G96881BQ	pNp +EDTA	10935626
UDP-GlcNAc	G71142DF	[beta]-pNp	10935626

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Mus musculus	NP_032520	NM_008494
Rattus norvegicus	NP_596884	NM_133393

KEGG BRITE Database

Orthology

K05948

Name

fringe [EC:2.4.1.222]

References

9187150

Rhea

RHEA:70531

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.222

PMID

RHEA:70511

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.222

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112361	spondylocostal dysostosis 3	Glyco-Disease Genes Database Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 44 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000008	Abnormal morphology of female internal genitalia
HP:0000023	Inguinal hernia
HP:0000028	Cryptorchidism
HP:0000047	Hypospadias
HP:0000069	Abnormality of the ureter
HP:0000175	Cleft palate
HP:0000252	Microcephaly
HP:0000256	Macrocephaly
HP:0000269	Prominent occiput

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:609813	spondylocostal dysostosis 3, autosomal recessive
ORPHA:2311	autosomal recessive spondylocostal dysostosis

PubChem Disease

MedGen Diseases

Spondylocostal dysostosis 3, autosomal recessive

OMIM Phenotypes

SPONDYLOCOSTAL DYSOSTOSIS 3, AUTOSOMAL RECESSIVE; SCDO3

KEGG Diseases

Spondylocostal dysostosis

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying **all 7** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	16848	MGI:1095413
Rattus norvegicus	170905	RGD:620587
Drosophila melanogaster	40314	FB:FBgn0011591
Danio rerio	30158	ZFIN:ZDB-GENE-980605-16
Xenopus laevis	397855	Xenbase:XB-GENE-17334134
Xenopus laevis	100036937	Xenbase:XB-GENE-865754
Xenopus tropicalis	549805	Xenbase:XB-GENE-487975

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements