GlyCosmos Portal

Submissions

phospholipase C delta 1

Summary

Gene Symbol

PLCD1

Aliases

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Phospholipase C δ1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5333

HGNC

9060

KEGG Gene ID

hsa:5333

PubChem

5333

Alliance of Genome Resources

HGNC:9060

JoGo

PLCD1

TogoVar

PLCD1

Annotation

Keyword

Alternative splicing
Calcium
Disease variant
Glycoprotein
Hydrolase
Lipid degradation
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Transducer

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P51178	Phosphoinositide phospholipase C-delta-1 Phospholipase C-III Phospholipase C-delta-1
A0A384MR47
A8K8F9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
lipid metabolic process	IEA
phospholipid metabolic process	TAS
signal transduction	IEA
phospholipase C-activating G protein-coupled receptor signaling pathway	IDA
lipid catabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction

intracellular signaling cassette [inference]

phospholipase C/protein kinase C signal transduction

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

phosphatidylinositol metabolic process

catabolic process [inference]

lipid catabolic process

primary metabolic process [inference]

lipid metabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction

intracellular signaling cassette [inference]

phospholipase C/protein kinase C signal transduction

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
cytoplasm	IDA
cytoplasm	IBA
cytoplasm	IEA
cytosol	IEA
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying entries **1 - 5** of 17 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	PMID
phosphatidylserine binding
phosphatidylinositol-4,5-bisphosphate phospholipase C activity	EXP
phosphatidylinositol-4,5-bisphosphate phospholipase C activity	TAS
phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IDA
phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

glycerophospholipase activity [inference]

C-type glycerophospholipase activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity

C-type glycerophospholipase activity

binding [inference]

protein binding

GTPase activating protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol phosphate binding

phosphatidylinositol-4,5-bisphosphate binding

small molecule binding [inference]

ion binding [inference]

anion binding

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

modified amino acid binding [inference]

phosphatidylserine binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
calcium ion binding
hydrolase activity
lipid metabolic process
metal ion binding
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol

Displaying **all 8** entries
InterPro
C2 domain superfamily
C2 domain
EF-hand domain pair
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-specific phospholipase C, X domain
Phosphoinositide phospholipase C family
Phosphoinositide-specific phospholipase C, EF-hand-like domain
Phospholipase C, phosphatidylinositol-specific, Y domain

Human Protein Atlas

ENSG00000187091

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K05857

Name

phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]

References

Rhea

RHEA:33179

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

H⁺ + a 1,2-diacyl-sn-glycerol + 1D-myo-inositol 1,4,5-trisphosphate

Enzyme

3.1.4.11

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080081	nonsyndromic congenital nail disorder 3	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 15 in total

1

2

Next ›

Last »
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000498	Blepharitis
HP:0000499	Abnormal eyelash morphology
HP:0000613	Photophobia
HP:0000787	Nephrolithiasis
HP:0001231	Abnormal fingernail morphology
HP:0001595	Abnormal hair morphology
HP:0001598	Concave nail
HP:0001820	Leukonychia

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:151600	nonsyndromic congenital nail disorder 3
ORPHA:2387	leukonychia totalis nonsyndromic congenital nail disorder 3

PubChem Disease

MedGen Diseases

Nonsyndromic congenital nail disorder 3

OMIM Phenotypes

NAIL DISORDER, NONSYNDROMIC CONGENITAL, 3; NDNC3

KEGG Diseases

Nonsyndromic congenital nail disorder

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002087
Gene Name: phospholipase C, delta 1

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	18799	MGI:97614
Rattus norvegicus	24655	RGD:3346
Danio rerio	555443	ZFIN:ZDB-GENE-071004-78
Xenopus laevis	108718712	Xenbase:XB-GENE-6485790
Xenopus laevis	108719811	Xenbase:XB-GENE-17339244

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements