GlyCosmos Portal

Annotation

Keyword

Calcium
Glycoprotein
Hydrolase
Lipid degradation
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Transducer

Proteins

Displaying **all 2** entries
UniProt	Protein Name
G5DDB7
Q8R3B1	Phosphoinositide phospholipase C-delta-1 Phospholipase C-delta-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
angiogenesis	IGI	16314520
G protein-coupled receptor signaling pathway	ISO
phospholipase C-activating G protein-coupled receptor signaling pathway	ISO
positive regulation of norepinephrine secretion	ISO
lipid catabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organic substance catabolic process [inference]

lipid catabolic process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

blood vessel development [inference]

placenta blood vessel development [inference]

labyrinthine layer blood vessel development

animal organ development [inference]

embryonic organ development [inference]

labyrinthine layer blood vessel development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to calcium ion

response to peptide [inference]

response to peptide hormone

response to salt [inference]

response to calcium ion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

regulation of inositol trisphosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

regulation of inositol trisphosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

regulation of inositol trisphosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

regulation of inositol trisphosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of phosphate metabolic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

regulation of inositol trisphosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of small molecule metabolic process [inference]

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

regulation of inositol trisphosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of carbohydrate biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

regulation of inositol trisphosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of norepinephrine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of norepinephrine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

regulation of inositol trisphosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of phosphate metabolic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

regulation of inositol trisphosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol trisphosphate biosynthetic process

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of norepinephrine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of norepinephrine secretion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasm	ISO	15702972
cytoplasm	IBA
cytosol	IDA	15899900
plasma membrane	IBA
mitochondrial membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

mitochondrial membrane

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
phosphatidylserine binding
phosphatidylinositol phospholipase C activity	ISS
phosphatidylinositol phospholipase C activity	ISO
phosphatidylinositol phospholipase C activity	IBA
phosphatidylinositol phospholipase C activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity

phosphatidylinositol phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity

phosphatidylinositol phospholipase C activity

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

phosphatidic acid binding

small molecule binding [inference]

alcohol binding [inference]

inositol 1,4,5 trisphosphate binding

ion binding [inference]

anion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

modified amino acid binding [inference]

phosphatidylserine binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
lipid metabolic process
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol

Displaying **all 7** entries
InterPro
C2 domain superfamily
C2 domain
EF-hand domain pair
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-specific phospholipase C, X domain
Phosphoinositide phospholipase C family
Phospholipase C, phosphatidylinositol-specific, Y domain

Rhea

RHEA:33179

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

H⁺ + a 1,2-diacyl-sn-glycerol + 1D-myo-inositol 1,4,5-trisphosphate

Enzyme

3.1.4.11

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002929
Gene Name: phospholipase C, delta 1

Ortholog

Displaying entries **1 - 10** of **113** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	5330	SGD:S000006189
Saccharomyces cerevisiae S288C	5331	SGD:S000006189
Saccharomyces cerevisiae S288C	5332	SGD:S000006189
Homo sapiens	5333	Xenbase:XB-GENE-1013054	HUMAN69194
Saccharomyces cerevisiae S288C	5334	SGD:S000006189
Saccharomyces cerevisiae S288C	5335	SGD:S000006189
Saccharomyces cerevisiae S288C	5336	SGD:S000006189
Saccharomyces cerevisiae S288C	9651	SGD:S000006189
Saccharomyces cerevisiae S288C	18797	SGD:S000006189
Xenopus tropicalis	18799	Xenbase:XB-GENE-1013054

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements