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angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

Summary

Gene Symbol

ace

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

565980

KEGG Gene ID

PubChem

565980

Alliance of Genome Resources

ZFIN:ZDB-GENE-030131-1826

Annotation

Keyword

Carboxypeptidase
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Proteomics identification
Reference proteome
Signal
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
E7FFA5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
angiotensin maturation	IBA
positive regulation of systemic arterial blood pressure	IBA
proteolysis	IEA
regulation of intestinal epithelial structure maintenance	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

biological regulation [inference]

regulation of biological process [inference]

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

regulation of intestinal epithelial structure maintenance

regulation of biological quality [inference]

regulation of blood pressure [inference]

positive regulation of blood pressure [inference]

positive regulation of systemic arterial blood pressure

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	IBA
obsolete extracellular space
plasma membrane	IBA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane

plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
carboxypeptidase activity
peptidase activity	IEA
metallopeptidase activity	IBA
metallopeptidase activity	IEA
peptidyl-dipeptidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

metallopeptidase activity

exopeptidase activity [inference]

catalytic activity, acting on a protein [inference]

peptidase activity

metallopeptidase activity

exopeptidase activity [inference]

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

angiotensin-converting enzyme

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
carboxypeptidase activity
hydrolase activity
metal ion binding
metallopeptidase activity
peptidyl-dipeptidase activity
positive regulation of systemic arterial blood pressure
proteolysis
regulation of systemic arterial blood pressure by renin-angiotensin

Displaying 1 entry
InterPro
Peptidase M2, peptidyl-dipeptidase A

Ortholog

Displaying **all 9** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11421	MGI:87874
Mus musculus	217246	MGI:3644400
Rattus norvegicus	24310	RGD:2493
Rattus norvegicus	498012	RGD:1561299
Caenorhabditis elegans	180780	WB:WBGene00000039
Drosophila melanogaster	34805	FB:FBgn0012037
Drosophila melanogaster	34189	FB:FBgn0016122
Homo sapiens	1636	HGNC:2707
Xenopus tropicalis	100144634	Xenbase:XB-GENE-479789