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core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

Summary

Gene Symbol

C1GALT1

Aliases

C1GALT
T-synthase
core 1 beta3-Gal-T

Organism

Homo sapiens (human)

External Links

NCBI Gene

56913

GGDB ID

gg075

HGNC

24337

mRNA

NM_020156

map

7p14-p13

Protein

NP_064541

OMIM

610555

KEGG Gene ID

hsa:56913

PubChem

56913

Alliance of Genome Resources

HGNC:24337

JoGo

C1GALT1

TogoVar

C1GALT1

Annotation

Keyword

Alternative splicing
Angiogenesis
Developmental protein
Differentiation
Disulfide bond
Glycosyltransferase
Manganese
Metal-binding
Nucleotide-binding
Phosphoprotein
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9NS00	B3Gal-T8 Core 1 O-glycan T-synthase Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1 Core 1 beta1,3-galactosyltransferase 1
A0A024RA32	Core 1 O-glycan T-synthase Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1 Core 1 beta1,3-galactosyltransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
angiogenesis	IMP
angiogenesis	IEA
kidney development	IMP
protein O-linked glycosylation
intestinal epithelial cell development

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

columnar/cuboidal epithelial cell development [inference]

intestinal epithelial cell development

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

columnar/cuboidal epithelial cell development [inference]

intestinal epithelial cell development

animal organ development [inference]

kidney development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

columnar/cuboidal epithelial cell development [inference]

intestinal epithelial cell development

Displaying **all 4** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
membrane	ISS
membrane	IDA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleotide binding
protein binding	IPI
N-acetylgalactosaminide beta-1,3-galactosyltransferase activity	IDA
N-acetylgalactosaminide beta-1,3-galactosyltransferase activity	IBA
N-acetylgalactosaminide beta-1,3-galactosyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

N-acetylgalactosaminide beta-1,3-galactosyltransferase activity

hexosyltransferase activity [inference]

galactosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

N-acetylgalactosaminide beta-1,3-galactosyltransferase activity

beta-1,3-galactosyltransferase activity [inference]

N-acetylgalactosaminide beta-1,3-galactosyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

N-acetylgalactosaminide beta-1,3-galactosyltransferase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding

nucleoside phosphate binding [inference]

nucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000106392

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg075

Gene Symbol

C1GALT1

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
(not applicable)	G57321FI	Ser/Thr	G00031MO	Ser/Thr	11677243

Displaying **all 3** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
(not applicable)	G57321FI	Ser/Thr	G00031MO	Ser/Thr	11677243
UDP-Gal	G57321FI	PSGL-1(EYEYLDYDFLPETEPPEM)	G00031MO	PSGL-1(EYEYLDYDFLPETEPPEM)	11677243
UDP-Gal	G57321FI	O-glycan Synthesis	G00031MO	O-glycan Synthesis

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-Gal	G00035MO	O-glycan Synthesis

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Caenorhabditis elegans	NP_499293	NM_066892
Mus musculus	NP_443719	NM_052993
Drosophila melanogaster	NP_723428	NM_164840
Rattus norvegicus	NP_075239	NM_022950

KEGG BRITE Database

Orthology

K00731

Name

glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase [EC:2.4.1.122]

References

11677243

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05908	2.4.1.122	G57321FI	G00031MO

Rhea

RHEA:15621

an N-acetyl-α-D-galactosaminyl derivative + UDP-α-D-galactose

a β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + H⁺ + UDP

Enzyme

2.4.1.122

PMID

Ortholog

Displaying entries **1 - 10** of 14 in total

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Species	Gene ID	Alliance of Genome Resources
Mus musculus	94192	MGI:2151071
Rattus norvegicus	65044	RGD:621105
Caenorhabditis elegans	176455	WB:WBGene00008019
Drosophila melanogaster	32896	FB:FBgn0030984
Drosophila melanogaster	33485	FB:FBgn0031472
Drosophila melanogaster	34215	FB:FBgn0032078
Drosophila melanogaster	35792	FB:FBgn0033271
Drosophila melanogaster	33482	FB:FBgn0031469
Danio rerio	555344	ZFIN:ZDB-GENE-060503-810
Danio rerio	557675	ZFIN:ZDB-GENE-061013-303

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements