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junctional adhesion molecule 2

Summary

Gene Symbol

JAM2

Organism

Homo sapiens (human)

External Links

NCBI Gene

58494

PubChem

58494

Alliance of Genome Resources

HGNC:14686

Annotation

Keyword

Alternative splicing
Cell membrane
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Immunoglobulin domain
Reference proteome
Signal
Tight junction
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P57087	Junctional adhesion molecule 2 Vascular endothelial junction-associated molecule

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
leukocyte cell-cell adhesion	IBA
spermatid development	ISS
myoblast fusion
negative regulation of myelination	ISS
maintenance of blood-brain barrier	NAS	30280653

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

cellular extravasation

cellular process [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

cell adhesion [inference]

cell-cell adhesion

leukocyte cell-cell adhesion

leukocyte adhesion to vascular endothelial cell [inference]

leukocyte tethering or rolling

leukocyte aggregation [inference]

lymphocyte aggregation

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

spermatid development

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

spermatid development

cell motility [inference]

cell migration [inference]

hematopoietic stem cell migration [inference]

hematopoietic stem cell migration to bone marrow

leukocyte migration [inference]

cellular extravasation

cell-cell fusion [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

spermatid development

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

spermatid development

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

spermatid development

anatomical structure formation involved in morphogenesis [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

anatomical structure development [inference]

cell development [inference]

germ cell development [inference]

spermatid development

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

spermatid development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of myelination

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

negative regulation of myelination

regulation of cellular process [inference]

regulation of myelination [inference]

negative regulation of myelination

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

negative regulation of cellular process [inference]

negative regulation of myelination

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

negative regulation of myelination

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
plasma membrane	NAS	10779521
plasma membrane	TAS
plasma membrane	IDA	11590146
plasma membrane	IMP	31851307
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein complex involved in cell adhesion

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone

tight junction

bicellular tight junction

somatodendritic compartment

Displaying **all 2** entries
GO Term	Evidence Code	PMID
integrin binding	IDA	12070135
protein binding	IPI	11590146 11823489 21982860

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Immunoglobulin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060230	basal ganglia calcification	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 67 in total

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Species	Gene ID	Orthologous MAtrix
Taeniopygia guttata	100227766	TAEGU09828
Callithrix jacchus	100410670	CALJA22436
Macaca mulatta	100427824	MACMU32385
Pongo abelii	100436752	PONAB21325
Ailuropoda melanoleuca	100467834	AILME11944
Nomascus leucogenys	100585596	NOMLE23613
Oreochromis niloticus	100695373	ORENI45515
Sarcophilus harrisii	100916278	SARHA13199
Otolemur garnettii	100949841	OTOGA16951
Pan paniscus	100968362	PANPA22853