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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

solute carrier family 22 member 2

Summary

Gene Symbol

SLC22A2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6582

KEGG Gene ID

PubChem

6582

Alliance of Genome Resources

HGNC:10966

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Glycoprotein
Ion transport
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O15244	Organic cation transporter 2

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
monoatomic cation transport
neurotransmitter transport	TAS
neurotransmitter transport	IDA
serotonin transport	IDA
body fluid secretion

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

vitamin transmembrane transport [inference]

thiamine transmembrane transport

azole transmembrane transport [inference]

thiamine transmembrane transport

purine-containing compound transmembrane transport

pyrimidine-containing compound transmembrane transport [inference]

thiamine transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

export across plasma membrane

polyamine transmembrane transport [inference]

spermidine transmembrane transport

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport

export from cell [inference]

export across plasma membrane

cellular detoxification

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

xenobiotic transport across blood-brain barrier

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport

neurotransmitter transport

neurotransmitter uptake [inference]

histamine uptake

neurotransmitter reuptake [inference]

serotonin uptake

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

basic amino acid transport [inference]

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport [inference]

L-alpha-amino acid transmembrane transport

lipid transport [inference]

fatty acid transport [inference]

prostaglandin transport

vascular transport [inference]

transport across blood-brain barrier

xenobiotic transport across blood-brain barrier

organic cation transport

putrescine transport

spermidine transport

spermidine transmembrane transport

norepinephrine transport

norepinephrine uptake

thiamine transport [inference]

thiamine transmembrane transport

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

prostaglandin transport

L-amino acid transport [inference]

L-alpha-amino acid transmembrane transport

icosanoid transport [inference]

prostaglandin transport

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

prostaglandin transport

L-amino acid transport [inference]

L-alpha-amino acid transmembrane transport

icosanoid transport [inference]

prostaglandin transport

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport

organic hydroxy compound transport [inference]

serotonin transport

serotonin uptake

catecholamine transport [inference]

dopamine transport

dopamine uptake

norepinephrine transport

norepinephrine uptake

epinephrine transport

catecholamine uptake [inference]

xenobiotic transport

xenobiotic transport across blood-brain barrier

secretion [inference]

body fluid secretion

vitamin transport [inference]

thiamine transport [inference]

thiamine transmembrane transport

vitamin transmembrane transport [inference]

thiamine transmembrane transport

transmembrane transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

vitamin transmembrane transport [inference]

thiamine transmembrane transport

azole transmembrane transport [inference]

thiamine transmembrane transport

purine-containing compound transmembrane transport

pyrimidine-containing compound transmembrane transport [inference]

thiamine transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

export across plasma membrane

polyamine transmembrane transport [inference]

spermidine transmembrane transport

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport

nitrogen compound transport [inference]

quaternary ammonium group transport

L-amino acid transport [inference]

L-alpha-amino acid transmembrane transport

amine transport

monoamine transport [inference]

serotonin transport

serotonin uptake

catecholamine transport [inference]

dopamine transport

dopamine uptake

norepinephrine transport

norepinephrine uptake

epinephrine transport

catecholamine uptake [inference]

polyamine transport [inference]

putrescine transport

spermidine transport

spermidine transmembrane transport

polyamine transmembrane transport [inference]

spermidine transmembrane transport

thiamine transport [inference]

thiamine transmembrane transport

azole transmembrane transport [inference]

thiamine transmembrane transport

histamine transport

histamine uptake

purine-containing compound transmembrane transport

pyrimidine-containing compound transmembrane transport [inference]

thiamine transmembrane transport

sulfur compound transport [inference]

thiamine transport [inference]

thiamine transmembrane transport

import into cell [inference]

neurotransmitter uptake [inference]

histamine uptake

neurotransmitter reuptake [inference]

serotonin uptake

import across plasma membrane [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

export from cell [inference]

export across plasma membrane

acetate ester transport [inference]

acetylcholine transport

establishment of localization in cell [inference]

neurotransmitter reuptake [inference]

serotonin uptake

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

body fluid secretion

detoxification [inference]

cellular detoxification

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
membrane	TAS
membrane	IEA
basolateral plasma membrane	ISS
basolateral plasma membrane	IEA
apical plasma membrane	EXP

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

plasma membrane region [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

presynapse

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
amine transmembrane transporter activity	IDA
acetylcholine transmembrane transporter activity	IDA
neurotransmitter transmembrane transporter activity	TAS
neurotransmitter transmembrane transporter activity	IDA
monoamine transmembrane transporter activity	IDA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

amine transmembrane transporter activity

neurotransmitter transmembrane transporter activity

acetylcholine transmembrane transporter activity

amino acid transmembrane transporter activity [inference]

basic amino acid transmembrane transporter activity [inference]

L-arginine transmembrane transporter activity

L-amino acid transmembrane transporter activity

L-arginine transmembrane transporter activity

polyamine transmembrane transporter activity [inference]

nucleobase-containing compound transmembrane transporter activity [inference]

nucleoside transmembrane transporter activity [inference]

pyrimidine nucleoside transmembrane transporter activity

toxin transmembrane transporter activity

active transmembrane transporter activity [inference]

monoamine transmembrane transporter activity

xenobiotic transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

L-amino acid transmembrane transporter activity

L-arginine transmembrane transporter activity

vitamin transmembrane transporter activity [inference]

thiamine transmembrane transporter activity

lipid transmembrane transporter activity [inference]

icosanoid transmembrane transporter activity [inference]

prostaglandin transmembrane transporter activity

acetate ester transmembrane transporter activity [inference]

acetylcholine transmembrane transporter activity

azole transmembrane transporter activity [inference]

thiamine transmembrane transporter activity

carbohydrate derivative transmembrane transporter activity [inference]

nucleoside transmembrane transporter activity [inference]

pyrimidine nucleoside transmembrane transporter activity

sulfur compound transmembrane transporter activity [inference]

thiamine transmembrane transporter activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3021	acute kidney failure	Alliance of Genome Resources

Ortholog

Displaying **all 7** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	20518	MGI:1335072
Rattus norvegicus	29503	RGD:61936
Caenorhabditis elegans	172841	WB:WBGene00003842
Drosophila melanogaster	42891	FB:FBgn0019952
Drosophila melanogaster	35334	FB:FBgn0032879
Drosophila melanogaster	36417	FB:FBgn0033778
Saccharomyces cerevisiae S288C	850462	SGD:S000000695

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026