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MIRAGE

UDP-glucuronate decarboxylase 1

Summary

Gene Symbol

UXS1

Aliases

FLJ23591
SDR6E1
UGD
short chain dehydrogenase/reductase family 6E, member 12

Organism

Homo sapiens (human)

External Links

NCBI Gene

80146

HGNC

17729

KEGG Gene ID

hsa:80146

PubChem

80146

Alliance of Genome Resources

HGNC:17729

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Decarboxylase
Glycoprotein
Golgi apparatus
NAD
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8NBZ7	UDP-glucuronate decarboxylase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
UDP-D-xylose biosynthetic process	IDA	22810237 25521717
UDP-D-xylose biosynthetic process	IEA
D-xylose metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

phosphorus metabolic process [inference]

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

pentose metabolic process [inference]

D-xylose metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

pentose metabolic process [inference]

D-xylose metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

pentose metabolic process [inference]

D-xylose metabolic process

carbohydrate derivative metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

phosphorus metabolic process [inference]

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
cytoplasm	IBA
Golgi cisterna membrane	IEA
extracellular exosome	HDA	19199708
catalytic complex	IDA	23656592

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
identical protein binding	IPI	23656592
protein homodimerization activity	IDA	23656592
UDP-glucuronate decarboxylase activity	IDA	22810237 23072385 23656592 25521717
UDP-glucuronate decarboxylase activity	IBA
NAD+ binding	IDA	22810237 23072385 25521717

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

carboxy-lyase activity [inference]

UDP-glucuronate decarboxylase activity

binding [inference]

protein binding [inference]

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

ion binding [inference]

anion binding [inference]

NAD+ binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Udp-glucuronic acid decarboxylase

Functional Category

G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 3** entries
Gene Ontology
D-xylose metabolic process
NAD+ binding
UDP-glucuronate decarboxylase activity

Displaying **all 2** entries
InterPro
NAD(P)-binding domain superfamily
NAD(P)-binding domain

KEGG BRITE Database

Orthology

K08678

Name

UDP-glucuronate decarboxylase [EC:4.1.1.35]

References

Rhea

H⁺ + UDP-α-D-glucuronate

CO₂ + UDP-α-D-xylose

Enzyme

4.1.1.35

PMID

Ortholog

Displaying entries **21 - 30** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Cricetulus griseus	100763471		CRIGR06211
Sarcophilus harrisii	100932696		SARHA05690
Otolemur garnettii	100941893		OTOGA08205
Pan paniscus	100969707		PANPA25443
Papio anubis	101018632		PAPAN09989
Takifugu rubripes	101062157		TAKRU24820
Ovis aries	101107778		SHEEP13809
Gorilla gorilla gorilla	101151874		GORGO24978
Oryzias latipes	101174710		ORYLA09566
Tursiops truncatus	101318087		TURTR02033

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Last updated: August 4, 2025