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Guidelines

MIRAGE

translation initiation factor eIF4G

Summary

Gene Symbol

TIF4632

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

852833

KEGG Gene ID

PubChem

852833

Alliance of Genome Resources

SGD:S000003017

Annotation

Keyword

Cytoplasm
Initiation factor
Phosphoprotein
RNA-binding
Reference proteome
Translation regulation

Proteins

Displaying 1 entry
UniProt	Protein Name
P39936	Translation initiation factor 4(4)-F(6) subunit gamma(3) protein 2 eIF4G2 mRNA cap-binding protein complex subunit p130

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
translational initiation	IDA
translational initiation	IMP
translational initiation	IBA
translational initiation	IEA
regulation of translational initiation	NAS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

translational initiation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly [inference]

membraneless organelle assembly [inference]

stress granule assembly

cellular component assembly [inference]

organelle assembly [inference]

membraneless organelle assembly [inference]

stress granule assembly

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
P-body	IDA
P-body	IEA
cytoplasm	IEA
ribosome	NAS
cytoplasmic stress granule	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

RNA cap binding complex [inference]

eukaryotic translation initiation factor 4F complex

cellular anatomical structure [inference]

cytoplasm

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

ribosome

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

intracellular organelle [inference]

intracellular membraneless organelle [inference]

ribosome

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
ATPase activator activity	ISS
RNA binding	IEA
mRNA binding	IDA
mRNA binding	IBA
mRNA binding	HDA

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding [inference]

mRNA binding

protein binding

translation initiation factor binding

molecular function regulator activity [inference]

molecular function activator activity [inference]

ATPase activator activity

translation factor activity [inference]

translation initiation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

initiation factor

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
InterPro
Armadillo-type fold
Eukaryotic translation initiation factor 4G1, eIF4E-binding domain
Initiation factor 4G
MIF4G-like, type 3
eIF4G, eIF4e-binding domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
cytoplasmic stress granule	PMID:17908917 PMID:18981231 PMID:19470581 PMID:26777405
P-body	PMID:23222640

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	208643	MGI:2384784
Mus musculus	13690	MGI:109207
Mus musculus	230861	MGI:1923935
Homo sapiens	1982	HGNC:3297
Homo sapiens	8672	HGNC:3298
Homo sapiens	1981	HGNC:3296

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026