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beta-1,4-galactosyltransferase 4

Summary

Gene Symbol

B4GALT4

Aliases

beta4Gal-T4

Organism

Homo sapiens (human)

External Links

NCBI Gene

8702

GGDB ID

gg080

HGNC

927

mRNA

NM_003778

map

3q13.3

Protein

NP_003769

OMIM

604015

KEGG Gene ID

hsa:8702

PubChem

8702

Alliance of Genome Resources

HGNC:927

JoGo

B4GALT4

TogoVar

B4GALT4

Annotation

Keyword

Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Manganese
Metal-binding
Proteomics identification
Reference proteome
Secreted
Signal
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
O60513	Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase Lactotriaosylceramide beta-1,4-galactosyltransferase N-acetyllactosamine synthase Nal synthase UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4
B3KM35
E7ETS9
B2RAZ5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
lactosylceramide biosynthetic process	IDA
carbohydrate metabolic process	IEA
lipid metabolic process	TAS
obsolete membrane lipid metabolic process
keratan sulfate proteoglycan biosynthetic process	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

lactosylceramide biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

lactosylceramide biosynthetic process

ceramide biosynthetic process [inference]

lactosylceramide biosynthetic process

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

lactosylceramide biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

keratan sulfate proteoglycan metabolic process [inference]

keratan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

lipid metabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process [inference]

lactosylceramide biosynthetic process

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process [inference]

lactosylceramide biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

lactosylceramide biosynthetic process

ceramide biosynthetic process [inference]

lactosylceramide biosynthetic process

lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

lactosylceramide biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

lactosylceramide biosynthetic process

ceramide biosynthetic process [inference]

lactosylceramide biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process [inference]

lactosylceramide biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

lactosylceramide biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

keratan sulfate proteoglycan metabolic process [inference]

keratan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

keratan sulfate proteoglycan metabolic process [inference]

keratan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

keratan sulfate proteoglycan biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

lactosylceramide biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process [inference]

lactosylceramide biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process [inference]

lactosylceramide biosynthetic process

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
Golgi apparatus	IDA
Golgi apparatus	IBA
Golgi apparatus	IEA
membrane	TAS
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IDA
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IEA
N-acetyllactosamine synthase activity	IDA
N-acetyllactosamine synthase activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

UDP-galactosyltransferase activity

hexosyltransferase activity [inference]

galactosyltransferase activity

UDP-galactosyltransferase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg080

Gene Symbol

B4GALT4

Reactions

Displaying **all 3** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-Gal	G21828TB	Cer	G24366HE	Cer	9792633
UDP-Gal	G55302WQ	R	G08863NS	R	17529980
UDP-Gal	G06239NA	Cer	G58896AZ	Cer	9792633

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Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-Gal	G85856KC		G28052FT		9792633
UDP-Gal	G43211QV		G71893QN		12511560
UDP-Gal	G00033MO	pNP	G64973KT	pNP	9857011
UDP-Gal	G21828TB	Cer	G24366HE	Cer	9792633
UDP-Gal	G23000DQ	octyl	G80671XL	octyl	9857011

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Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-Gal	G16579HJ	[beta]-1-4-methyl-umbelliferyl	9792633
UDP-Gal	G68544GH	[alpha]-1-o-Nitrophenyl	9792633
UDP-Gal	G61418DU	[beta]-1-4-methyl-umbelliferyl	9792633
UDP-Gal	G68544GH	[alpha]-1-Benzl	9792633
UDP-Gal	G65889KE	[beta]-1-4-methyl-umbelliferyl	9792633

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Mus musculus	NP_062778	NM_019804
Rattus norvegicus	XP_221439	XM_221439

KEGG BRITE Database

Orthology

K07969

Name

beta-1,4-galactosyltransferase 4 [EC:2.4.1.90 2.4.1.275 2.4.1.-]

References

9792633

Reactions

Displaying **all 3** entries
KEGG Reaction	Enzyme	Acceptor	Product
R07617	2.4.1.-	G00033MO	G64973KT
R06033	2.4.1.-	G70874WW	G84034JH
R05977	2.4.1.- 2.4.1.275	G06239NA	G58896AZ

Rhea

RHEA:31499

a β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + UDP-α-D-galactose

H⁺ + a neolactoside nLc4Cer(d18:1(4E)) + UDP

Enzyme

2.4.1.275

PMID

RHEA:17745

N-acetyl-D-glucosamine + UDP-α-D-galactose

H⁺ + UDP + β-D-galactosyl-(1→4)-N-acetyl-D-glucosamine

Enzyme

2.4.1.90

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002750
Gene Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4

Ortholog

Displaying **all 8** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	56375	MGI:1928387
Rattus norvegicus	303923	RGD:1307880
Caenorhabditis elegans	190668	WB:WBGene00000269
Drosophila melanogaster	36585	FB:FBgn0027538
Danio rerio	492760	ZFIN:ZDB-GENE-041114-103
Xenopus laevis	108707823	Xenbase:XB-GENE-17342416
Xenopus laevis	444709	Xenbase:XB-GENE-953814
Xenopus tropicalis	100488464	Xenbase:XB-GENE-953813

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements