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ADAM metallopeptidase with thrombospondin type 1 motif 4

Summary

Gene Symbol

ADAMTS4

Organism

Homo sapiens (human)

External Links

NCBI Gene

9507

KEGG Gene ID

PubChem

9507

Alliance of Genome Resources

HGNC:220

Annotation

Keyword

3D-structure
Alternative splicing
Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Metal-binding
Metalloprotease
Proteomics identification
Reference proteome
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
O75173	ADMP-1 Aggrecanase-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
skeletal system development	TAS
proteolysis	TAS
proteolysis	IBA
proteolysis	IEA
extracellular matrix disassembly	TAS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

protein metabolic process [inference]

proteolysis

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly

extracellular structure organization [inference]

extracellular matrix organization

extracellular matrix disassembly

external encapsulating structure organization [inference]

extracellular matrix organization

extracellular matrix disassembly

developmental process [inference]

anatomical structure development [inference]

system development [inference]

skeletal system development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
extracellular matrix	HDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

intracellular organelle [inference]

intracellular membraneless organelle [inference]

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

supramolecular complex [inference]

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
protease binding	IPI
metalloendopeptidase activity	TAS
metalloendopeptidase activity	IDA
metalloendopeptidase activity	IBA
metalloendopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding

enzyme binding [inference]

protease binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

A disintegrin and metalloproteinase with thrombospondin motifs

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
extracellular matrix organization
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 2** entries
InterPro
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	240913	MGI:1339949
Rattus norvegicus	66015	RGD:621242
Caenorhabditis elegans	177850	WB:WBGene00001650

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026

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Acknowledgements