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G00052MO

Summary

GlyTouCan ID: G00052MO
IUPAC Condensed: Fuc(a1-2)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-
Motifs: Blood group H (type 2) Leb Lewis b Ley
Subsumption Level: Fully-defined saccharide
Monoisotopic Mass: 675.26

External Links

GlyGen

G00052MO

ChEBI

59045

PubChem Compound

45266908

PubChem Substance

252284113

CarbBank

329 642 2537 2538 2539 3605 4591 7421 7648 7781 7847 10751 14878 15221 16398 20238 22552 22553 22554 22555 23607 25838 27637 28542 28578 28581 28594 29591 34222 34676 34848 34944 34976 34984 35241 35825 35841 36884 36921 36945 37036 37265 38055 41388 42058 42330 42425 42873 42934 43451 43710 44221 44361 44371 44543 45121 45320 45465 45861 45867 45900 45905 46554 46775 47008 47073 47183 47330 47457 48385 48510 48721 49120 49149 49439 50275 50533

3D Structures

GLYCAM: LFucpa1-2DGalpb1-4[LFucpa1-3]DGlcpNAcb1-OH

GlycoShape

G00052MO

Displaying 1 entry
Archetype	α	β
G04690JX	G82236PZ	G00052MO

Organisms

Displaying entries **1 - 5** of 15 in total

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Organisms	Evidence
Oryctolagus cuniculus (rabbit)	GlyTouCan(glycome-db)
Chlorocebus aethiops (grivet)	GlyTouCan(glycome-db)
Felis catus (domestic cat)	GlyTouCan(glycome-db)
Helicobacter pylori	GlyTouCan(bcsdb) GlyTouCan(glycome-db)
Mus musculus (house mouse)	GlyTouCan(glycome-db)

Taxonomic Hierarchy

root

Viruses [inference]

Riboviria [inference]

Pararnavirae [inference]

Artverviricota [inference]

Revtraviricetes [inference]

Ortervirales [inference]

Retroviridae [inference]

Orthoretrovirinae [inference]

Lentivirus [inference]

Primate lentivirus group [inference]

unclassified Primate lentivirus group [inference]

Human immunodeficiency virus

Human immunodeficiency virus 1

cellular organisms [inference]

Bacteria (eubacteria) [inference]

Campylobacterota [inference]

Epsilonproteobacteria [inference]

Campylobacterales [inference]

Helicobacteraceae [inference]

Helicobacter [inference]

Helicobacter pylori

Eukaryota (eucaryotes) [inference]

Opisthokonta [inference]

Metazoa (metazoans) [inference]

Eumetazoa [inference]

Bilateria [inference]

Deuterostomia [inference]

Chordata (chordates) [inference]

Craniata [inference]

Vertebrata (vertebrates) [inference]

Gnathostomata (jawed vertebrates) [inference]

Teleostomi [inference]

Euteleostomi (bony vertebrates) [inference]

Sarcopterygii [inference]

Dipnotetrapodomorpha [inference]

Tetrapoda (tetrapods) [inference]

Amniota (amniotes) [inference]

Mammalia (mammals) [inference]

Theria [inference]

Eutheria (placentals) [inference]

Boreoeutheria [inference]

Laurasiatheria [inference]

Carnivora (carnivores) [inference]

Feliformia [inference]

Felidae (cat family) [inference]

Felinae [inference]

Felis [inference]

Felis catus (domestic cat)

Caniformia [inference]

Canidae (dog, coyote, wolf, fox) [inference]

Canis [inference]

Canis lupus (gray wolf) [inference]

Canis lupus familiaris (dog)

Artiodactyla (even-toed ungulates & whales) [inference]

Ruminantia [inference]

Pecora [inference]

Bovidae [inference]

Bovinae [inference]

Bos (cattle) [inference]

Bos taurus (domestic cattle)

Suina [inference]

Suidae (pigs) [inference]

Sus [inference]

Sus scrofa (pig)

Euarchontoglires [inference]

Glires (Rodents and rabbits) [inference]

Lagomorpha [inference]

Leporidae (rabbits and hares) [inference]

Oryctolagus [inference]

Oryctolagus cuniculus (rabbit)

Rodentia (rodent) [inference]

Myomorpha (mice and others) [inference]

Muroidea [inference]

Cricetidae [inference]

Cricetinae (hamsters) [inference]

Mesocricetus [inference]

Mesocricetus auratus (golden hamster)

Muridae [inference]

Murinae [inference]

Rattus

Mus (mice) [inference]

Mus [inference]

Mus musculus (house mouse)

Primates [inference]

Haplorrhini [inference]

Simiiformes [inference]

Catarrhini [inference]

Hominoidea (apes) [inference]

Hominidae (great apes) [inference]

Homininae [inference]

Homo [inference]

Homo sapiens (human)

Cercopithecoidea [inference]

Cercopithecidae (Old World monkeys) [inference]

Cercopithecinae [inference]

Chlorocebus [inference]

Chlorocebus aethiops (grivet)

GlycoGene Database (GGDB)

Displaying **all 2** entries
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
FUT5	GDP-Fuc	G61459JW	R	G00052MO	R	16484342
FUT3	GDP-Fuc	G61459JW	R	G00052MO	R	7721776

Displaying **all 5** entries
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
FUT5	GDP-Fuc	G61459JW	R	G00052MO	R	16484342
FUT5	GDP-Fuc	G61459JW	(CH2)8COOCH3	G00052MO	(CH2)8COOCH3	9079712
FUT3	GDP-Fuc	G61459JW	R	G00052MO	R	7721776
FUT3	GDP-Fuc	G61459JW	(CH2)8COOCH3	G00052MO	(CH2)8COOCH3	9079712
FUT6	GDP-Fuc	G61459JW	(CH2)8COOCH3	G00052MO	(CH2)8COOCH3	9079712

GlycoEpitope

Epitope ID: EP0018

Sequence Descriptors

GlycoCT

RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:a-lgal-HEX-1:5|6:d
4b:b-dgal-HEX-1:5
5b:a-lgal-HEX-1:5|6:d
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:1o(4+1)4d
4:4o(2+1)5d

WURCS

WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5][a2112h-1b_1-5]/1-2-3-2/a3-b1_a4-c1_c2-d1

Literature

Displaying entries **311 - 320** of **410** in total

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PubMed ID	Title	First Author	Publication Date	Source
9797366	Lack of correlation between Lewis antigen expression by Helicobacter pylori and gastric epithelial cells in infected patients	Taylor DE	1998 Nov	PubChem
9824007	Prognostic Significance of Lewis y Antigen in Resected Stage I and II Non-small Cell Lung Cancer	Mehdi SA	1998 Nov	PubChem
9648430	[Pathophysiological mechanism of Helicobacter infections--host factors]	Sugiyama T	1998 May 10	PubChem
9565568	Simultaneous expression of type 1 and type 2 Lewis blood group antigens by Helicobacter pylori lipopolysaccharides. Molecular mimicry between h. pylori lipopolysaccharides and human gastric epithelial cell surface glycoforms	Monteiro MA	1998 May 08	BCSDB GlyGen PubChem
9647575	Immunolocalization of Le(y) oligosaccharide in endometrium during menstrual cycle and effect of early luteal phase mifepristone administration on its expression in implantation stage endometrium of the rhesus monkey	Ghosh D	1998 May 01	PubChem
9593187	THE CRYSTAL STRUCTURE OF THE DISULFIDE-STABILIZED FV FRAGMENT OF ANTICANCER ANTIBODY B1: CONFORMATIONAL INFLUENCE OF AN ENGINEERED DISULFIDE BOND	Almog O	1998 May 01	PubChem
9570276	Effects of monoclonal antibody directed to LeY on implantation in the mouse	Wang XQ	1998 Mar 01	PubChem
9498776	Analysis of BR96 Binding Sites for Antigen and Anti-Idiotype by Codon-Based Scanning Mutagenesis	Rosok MJ	1998 Mar 01	PubChem
9659270	Evidence of novel pathogenic pathways for the formation of antigastric autoantibodies in Helicobacter pylori gastritis.	Faller G	1998 Mar	PubChem
9592128	Expression of Lex antigen in Schistosoma japonicum and S.haematobium and immune responses to Lex in infected animals: Lack of Lex expression in other trematodes and nematodes	Nyame AK	1998 Jun 01	PubChem

PubAnnotation

Displaying entries **1 - 5** of 10 in total

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Title	Authors	Source	Publication Date	PubMed ID
Development of potent monoclonal antibody auristatin conjugates for cancer therapy.	Doronina SO Toki BE Torgov MY Mendelsohn BA Cerveny CG Chace DF DeBlanc RL Gearing RP Bovee TD Siegall CB Francisco JA Wahl AF Meyer DL Senter PD	Nat Biotechnol	2003 Jul	12778055
The expression of free oligosaccharides in human seminal plasma.	Chalabi S Easton RL Patankar MS Lattanzio FA Morrison JC Panico M Morris HR Dell A Clark GF	J Biol Chem	2002 Sep 6	12063266
Phenotypic variation in molecular mimicry between Helicobacter pylori lipopolysaccharides and human gastric epithelial cell surface glycoforms. Acid-induced phase variation in Lewis(x) and Lewis(y) expression by H. Pylori lipopolysaccharides.	Moran AP Knirel YA Senchenkova SN Widmalm G Hynes SO Jansson PE	J Biol Chem	2002 Feb 22	11741906
Pursuit of optimal carbohydrate-based anticancer vaccines: preparation of a multiantigenic unimolecular glycopeptide containing the Tn, MBr1, and Lewis(y) antigens.	Allen JR Harris CR Danishefsky SJ	J Am Chem Soc	2001 Mar 7	11456809
The fucosylated histo-blood group antigens H type 2 (blood group O, CD173) and Lewis Y (CD174) are expressed on CD34+ hematopoietic progenitors but absent on mature lymphocytes.	Cao Y Merling A Karsten U Schwartz-Albiez R	Glycobiology	2001 Aug	11479278

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

GlycoEpitope

Sequence Descriptors

International Collaboration

Acknowledgements