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MIRAGE
G46677TE

Summary
GlyTouCan ID
G46677TE
IUPAC Condensed
Neu5Ac(a2-3)[Neu5Ac(a2-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-
Motifs
GD1a
Subsumption Level
Fully-defined saccharide
Monoisotopic Mass
1289.44
GlyGen
ChEBI
PubChem Compound
PubChem Substance
GlycoShape
Displaying 1 entry
Archetype α β
G21518JT
G01633SK
G46677TE
3D Structures
GlycoShape
G46677TE
GLYCAM
Neup5Aca2-3[Neup5Aca2-3DGalpb1-3DGalpNAcb1-4]DGalpb1-4DGlcpb1-OH
Organisms
Displaying entries 1 - 5 of 20 in total
Organisms Evidence
Oncorhynchus mykiss (rainbow trout)
Meleagris gallopavo (turkey)
Mus musculus (house mouse)
Cricetulus griseus (Chinese hamster)
Gallus gallus (chicken)
Taxonomic Hierarchy
GlycoGene Database (GGDB)
Displaying 1 entry
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
ST8SIA5 CMP-Neu5Ac
G46677TE
Cer
G68110IF
Cer
Displaying entries 1 - 5 of 6 in total
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
ST8SIA5 CMP-Neu5Ac
G46677TE
Cer
G68110IF
Cer
ST8SIA5 CMP-Neu5Ac
G46677TE
Cer
G40183QN
Cer
ST8SIA6 CMP-Neu5Ac
G46677TE
Cer
G40183QN
Cer
ST3GAL2 CMP-Neu5Ac
G48558GR
Cer
G46677TE
Cer
ST3GAL1 CMP-Neu5Ac
G48558GR
ceramide
G46677TE
ceramide
Displaying entries 1 - 5 of 6 in total
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Reference
ST6GALNAC2 CMP-Neu5Ac
G46677TE
ceramide
ST6GALNAC4 CMP-Neu5Ac
G46677TE
ceramide
ST8SIA2 CMP-Neu5Ac
G46677TE
Cer
ST3GAL6 CMP-Neu5Ac
G46677TE
ceramide
ST8SIA3 CMP-Neu5Ac
G46677TE
Cer
KEGG BRITE Database
KEGG ID
Enzyme
References
Reactions
Displaying all 3 entries
KEGG Reaction Enzyme Acceptor Product
R05943
R05942
R05945
GlycoEpitope
Epitope ID
EP0056
Epitope Name
GD1a
Sequence Descriptors
GlycoCT
RES
1b:b-dglc-HEX-1:5
2b:b-dgal-HEX-1:5
3b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
4s:n-acetyl
5b:b-dgal-HEX-1:5
6s:n-acetyl
7b:b-dgal-HEX-1:5
8b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
9s:n-acetyl
LIN
1:1o(4+1)2d
2:2o(3+2)3d
3:3d(5+1)4n
4:2o(4+1)5d
5:5d(2+1)6n
6:5o(3+1)7d
7:7o(3+2)8d
8:8d(5+1)9n
WURCS
WURCS=2.0/4,6,5/[a2122h-1b_1-5][a2112h-1b_1-5][Aad21122h-2a_2-6_5*NCC/3=O][a2112h-1b_1-5_2*NCC/3=O]/1-2-3-4-2-3/a4-b1_b3-c2_b4-d1_d3-e1_e3-f2
Literature
Displaying entries 1 - 10 of 45 in total
PubMed ID Title First Author Publication Date Source
32957706 Structural and Biochemical Characterization of Botulinum Neurotoxin Subtype B2 Binding to Its Receptors Davies JR 2020 Sep 17
  • PubChem
32182233 Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy Yin L 2020 Mar 17
  • PubChem
28645943 The structure of the tetanus toxin reveals <scp>pH</scp>‐mediated domain dynamics Masuyer G 2017 Jun 23
  • PubChem
23807078 Structure of dual receptor binding to botulinum neurotoxin B Berntsson RP 2013 Jun 28
  • PubChem
21151139 The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis Nilsson EC 2010 Dec 12
  • PubChem
19726417 Chronic ataxic neuropathies associated with anti-GD1b IgM antibodies: response to IVIg therapy Attarian S 2009 Sep 01
  • PubChem
18704164 Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction Stenmark P 2008 Aug 15
  • PubChem
17855742 Sulfatide binding properties of murine and human antiganglioside antibodies Townson K 2007 Aug 17
  • GlyGen
  • GlycoEpitope
16614007 Anti-ganglioside complex antibodies in Miller Fisher syndrome Kaida K 2006 May 18
  • PubChem
15850580 AIDP and CIDP having specific antibodies to the carbohydrate epitope (-NeuAcalpha2-8NeuAcalpha2-3Galbeta1-4Glc-) of gangliosides Usuki S 2005 May 15
  • PubChem
PubAnnotation
Displaying entries 6 - 10 of 10 in total
Title Authors Source Publication Date PubMed ID
Specific ganglioside changes in extraneural tissues of adult rats with hypothyroidism.
  • Saito M
  • Sugiyama K
 Biochim Biophys Acta 2000 Oct 18 11042389
Activation of human T lymphocytes by ganglioside-containing liposomes.
  • Yanagihara K
  • Kato E
  • Hitomi S
  • Sunamoto J
  • Wada H
 Glycoconj J 1999 Jan 10580651
Gangliosides of Echinococcus multilocularis metacestodes.
  • Persat F
  • Bouhours JF
  • Petavy AF
  • Mojon M
 Biochim Biophys Acta 1994 Feb 22 8312377
Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.
  • Merrill AH Jr
  • van Echten G
  • Wang E
  • Sandhoff K
 J Biol Chem 1993 Dec 25 8262970
Inhibitory effects of gangliosides on immune reactions of antibodies to neutral glycolipids in liposomes.
  • Shichijo S
  • Alving CR
 Biochim Biophys Acta 1986 Jun 13 3707956
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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