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G46677TE

Summary

GlyTouCan ID: G46677TE
IUPAC Condensed: Neu5Ac(a2-3)[Neu5Ac(a2-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-
Motifs: GD1a
Subsumption Level: Fully-defined saccharide
Monoisotopic Mass: 1289.44

External Links

GlyGen

G46677TE

ChEBI

59209

PubChem Compound

45266861

PubChem Substance

252282546

GlycoShape

Displaying 1 entry
Archetype	α	β
G21518JT	G01633SK	G46677TE

3D Structures

GlycoShape: G46677TE
GLYCAM: Neup5Aca2-3[Neup5Aca2-3DGalpb1-3DGalpNAcb1-4]DGalpb1-4DGlcpb1-OH

Organisms

Displaying entries **16 - 20** of 20 in total

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Organisms	Evidence
Tursiops truncatus (common bottlenose dolphin)	GlyTouCan(glycome-db)
Cricetinae (hamsters)	GlyTouCan(glycome-db)
Parophrys vetulus (English sole)	GlyTouCan(glycome-db)
Sus scrofa (pig)	GlyTouCan(glycome-db)
Bos taurus (domestic cattle)	GlyTouCan(glycome-db)

Taxonomic Hierarchy

root

cellular organisms [inference]

Eukaryota (eucaryotes) [inference]

Opisthokonta [inference]

Metazoa (metazoans) [inference]

Eumetazoa [inference]

Bilateria [inference]

Deuterostomia [inference]

Chordata (chordates) [inference]

Craniata [inference]

Vertebrata (vertebrates) [inference]

Gnathostomata (jawed vertebrates) [inference]

Teleostomi [inference]

Euteleostomi (bony vertebrates) [inference]

Actinopterygii (ray-finned fishes) [inference]

Actinopteri [inference]

Neopterygii [inference]

Teleostei (teleost fishes) [inference]

Osteoglossocephalai [inference]

Clupeocephala [inference]

Euteleosteomorpha [inference]

Protacanthopterygii [inference]

Salmoniformes (salmons and trouts) [inference]

Salmonidae (salmonids) [inference]

Salmoninae (trouts, salmons & chars) [inference]

Oncorhynchus [inference]

Oncorhynchus mykiss (rainbow trout)

Neoteleostei [inference]

Eurypterygia [inference]

Ctenosquamata [inference]

Acanthomorphata [inference]

Euacanthomorphacea [inference]

Percomorphaceae [inference]

Carangaria [inference]

Pleuronectiformes (flatfishes) [inference]

Pleuronectoidei [inference]

Pleuronectidae (righteye flounders) [inference]

Parophrys [inference]

Parophrys vetulus (English sole)

Ovalentaria [inference]

Cichlomorphae [inference]

Cichliformes (cichlids and convict blennies) [inference]

Cichlidae (cichlids)

Otomorpha [inference]

Ostariophysi [inference]

Otophysi [inference]

Cypriniphysae [inference]

Cypriniformes (carps and others) [inference]

Cyprinoidei [inference]

Cyprinidae [inference]

Cyprininae [inference]

Carassius [inference]

Carassius auratus (goldfish)

Sarcopterygii [inference]

Dipnotetrapodomorpha [inference]

Tetrapoda (tetrapods) [inference]

Amniota (amniotes) [inference]

Sauropsida (sauropsids) [inference]

Sauria (diapsids) [inference]

Archelosauria [inference]

Archosauria [inference]

Dinosauria [inference]

Saurischia [inference]

Theropoda [inference]

Coelurosauria [inference]

Aves (birds) [inference]

Neognathae [inference]

Galloanserae [inference]

Galliformes (landfowls) [inference]

Phasianidae (turkeys) [inference]

Meleagridinae [inference]

Meleagris [inference]

Meleagris gallopavo (turkey)

Phasianinae [inference]

Gallus [inference]

Gallus gallus (chicken)

Mammalia (mammals) [inference]

Theria [inference]

Eutheria (placentals) [inference]

Boreoeutheria [inference]

Laurasiatheria [inference]

Artiodactyla (even-toed ungulates & whales) [inference]

Ruminantia [inference]

Pecora [inference]

Bovidae [inference]

Bovinae [inference]

Bos (cattle) [inference]

Bos taurus (domestic cattle)

Suina [inference]

Suidae (pigs) [inference]

Sus [inference]

Sus scrofa (pig)

Whippomorpha [inference]

Cetacea (whales) [inference]

Odontoceti (tooth whales) [inference]

Delphinidae (marine dolphins) [inference]

Tursiops [inference]

Tursiops truncatus (common bottlenose dolphin)

Carnivora (carnivores) [inference]

Feliformia [inference]

Felidae (cat family) [inference]

Felinae [inference]

Felis [inference]

Felis catus (domestic cat)

Eulipotyphla (hedgehogs, shrews, moles and others) [inference]

Soricidae (shrews)

Euarchontoglires [inference]

Glires (Rodents and rabbits) [inference]

Rodentia (rodent) [inference]

Myomorpha (mice and others) [inference]

Muroidea [inference]

Muridae [inference]

Murinae [inference]

Rattus

Mus (mice) [inference]

Mus [inference]

Mus musculus (house mouse)

Cricetidae [inference]

Cricetinae (hamsters)

Cricetulus [inference]

Cricetulus griseus (Chinese hamster)

Hystricomorpha (guinea pigs and others) [inference]

Chinchillidae (chinchillas)

Lagomorpha [inference]

Leporidae (rabbits and hares) [inference]

Oryctolagus [inference]

Oryctolagus cuniculus (rabbit)

Primates [inference]

Haplorrhini [inference]

Simiiformes [inference]

Catarrhini [inference]

Cercopithecoidea [inference]

Cercopithecidae (Old World monkeys) [inference]

Cercopithecinae [inference]

Papio (baboons) [inference]

Papio hamadryas (hamadryas baboon)

Hominoidea (apes) [inference]

Hominidae (great apes) [inference]

Homininae [inference]

Homo [inference]

Homo sapiens (human)

Discoba [inference]

Euglenozoa [inference]

Kinetoplastea (kinetoplasts) [inference]

Metakinetoplastina [inference]

Trypanosomatida [inference]

Trypanosomatidae [inference]

Leishmaniinae [inference]

Leishmania [inference]

Leishmania mexicana species complex [inference]

Leishmania amazonensis

GlycoGene Database (GGDB)

Displaying 1 entry
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
ST8SIA5	CMP-Neu5Ac	G46677TE	Cer	G68110IF	Cer	8910600

Displaying entries **1 - 5** of 6 in total

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Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
ST8SIA5	CMP-Neu5Ac	G46677TE	Cer	G68110IF	Cer	8910600
ST8SIA5	CMP-Neu5Ac	G46677TE	Cer	G40183QN	Cer	9199191
ST8SIA6	CMP-Neu5Ac	G46677TE	Cer	G40183QN	Cer	11980897 16120058
ST3GAL2	CMP-Neu5Ac	G48558GR	Cer	G46677TE	Cer	8920913
ST3GAL1	CMP-Neu5Ac	G48558GR	ceramide	G46677TE	ceramide	8027041

Displaying entries **1 - 5** of 6 in total

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Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Reference
ST6GALNAC2	CMP-Neu5Ac	G46677TE	ceramide	11062056
ST6GALNAC4	CMP-Neu5Ac	G46677TE	ceramide	11062056
ST8SIA2	CMP-Neu5Ac	G46677TE	Cer	7782326
ST3GAL6	CMP-Neu5Ac	G46677TE	ceramide	10206952
ST8SIA3	CMP-Neu5Ac	G46677TE	Cer	7782326 8910600

KEGG BRITE Database

KEGG ID

G00111

Enzyme

References

Reactions

Displaying **all 3** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05943	2.4.99.-	G46677TE	G68110IF
R05942	2.4.3.2	G48558GR	G46677TE
R05945		G46677TE	G02149VR

GlycoEpitope

Epitope ID: EP0056
Epitope Name: GD1a

Sequence Descriptors

GlycoCT

RES
1b:b-dglc-HEX-1:5
2b:b-dgal-HEX-1:5
3b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
4s:n-acetyl
5b:b-dgal-HEX-1:5
6s:n-acetyl
7b:b-dgal-HEX-1:5
8b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
9s:n-acetyl
LIN
1:1o(4+1)2d
2:2o(3+2)3d
3:3d(5+1)4n
4:2o(4+1)5d
5:5d(2+1)6n
6:5o(3+1)7d
7:7o(3+2)8d
8:8d(5+1)9n

WURCS

WURCS=2.0/4,6,5/[a2122h-1b_1-5][a2112h-1b_1-5][Aad21122h-2a_2-6_5*NCC/3=O][a2112h-1b_1-5_2*NCC/3=O]/1-2-3-4-2-3/a4-b1_b3-c2_b4-d1_d3-e1_e3-f2

Literature

Displaying entries **41 - 45** of 45 in total

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PubMed ID	Title	First Author	Publication Date	Source
8490240	Differential distribution of major gangliosides in rat central nervous system detected by specific monoclonal antibodies	Kotani M	1993 Apr	GlyGen GlycoEpitope
1627599	Generation of one set of monoclonal antibodies specific for a-pathway ganglio-series gangliosides	Kotani M	1992 Jul 21	GlyGen GlycoEpitope
2376746	Anticardiolipin antibodies in patients with rabies vaccination induced neurological complications and other neurological diseases	Chaleomchan W	1990 May	PubChem
2908845	Two human monoclonal antibodies reacting with the major gangliosides of human melanomas and comparison with corresponding mouse monoclonal antibodies	Furukawa K	1989 Jan 01	GlyGen GlycoEpitope
3031684	Cell-surface antigens of melanoma recognized by human monoclonal antibodies	Yamaguchi H	1987 Apr	GlyGen GlycoEpitope

PubAnnotation

Displaying entries **1 - 5** of 10 in total

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Title	Authors	Source	Publication Date	PubMed ID
Glycans Confer Specificity to the Recognition of Ganglioside Receptors by Botulinum Neurotoxin A.	Hamark C Berntsson RP Masuyer G Henriksson LM Gustafsson R Stenmark P Widmalm G	J Am Chem Soc	2017 Jan 11	27958736
Interfacial stabilization of the antitumoral drug Paclitaxel in monolayers of GM1 and GD1a gangliosides.	Heredia V Maggio B Beltramo DM Dupuy FG	Biochim Biophys Acta	2015 Oct	26119566
Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor.	Park SY Kwak CY Shayman JA Kim JH	Biochim Biophys Acta	2012 Jul	22542783
Direct binding of gangliosides to Helicobacter pylori vacuolating cytotoxin (VacA) neutralizes its toxin activity.	Wada A Hasegawa M Wong PF Shirai E Shirai N Tan LJ Llanes R Hojo H Yamasaki E Ichinose A Ichinose Y Senba M	Glycobiology	2010 Jun	20118071
Roles of complex gangliosides in the development of experimental autoimmune encephalomyelitis.	Miyamoto K Takada K Furukawa K Furukawa K Kusunoki S	Glycobiology	2008 May	18303055

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