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Sodium channel regulatory subunit beta-2

Summary

UniProt ID: O60939
Gene Symbol: SCN2B UNQ326/PRO386
Gene ID: 6327
Organism: Homo sapiens (human)

External Links

GlyGen: O60939
PubChem: O60939
The Human Metabolome Database: HMDBP09081
Re-Glyco: O60939

Annotation

Keyword: 3D-structure Atrial fibrillation Brugada syndrome Cell membrane Cell projection Disease variant Disulfide bond Glycoprotein Immunoglobulin domain Phosphoprotein Proteomics identification Reference proteome Signal Sodium transport Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
chemical synaptic transmission	TAS	PMID
nervous system development	IEA	GO_REF
response to heat
gene expression
positive regulation of sodium ion transport	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

cardiac muscle contraction

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

response to stimulus [inference]

response to stress [inference]

response to heat

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat

response to chemical [inference]

response to toxic substance [inference]

response to insecticide [inference]

response to pyrethroid

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of sodium ion transport [inference]

positive regulation of sodium ion transport

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

regulation of cellular process [inference]

regulation of membrane depolarization [inference]

regulation of atrial cardiac muscle cell membrane depolarization

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

cardiac conduction

regulation of heart rate by cardiac conduction

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of membrane potential [inference]

action potential [inference]

cardiac muscle cell action potential [inference]

cardiac muscle cell action potential involved in contraction

regulation of membrane depolarization [inference]

regulation of atrial cardiac muscle cell membrane depolarization

membrane depolarization [inference]

membrane depolarization during action potential

membrane depolarization during cardiac muscle cell action potential

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
voltage-gated sodium channel complex	TAS	PMID
voltage-gated sodium channel complex	IDA	PMID PMID PMID
voltage-gated sodium channel complex	IBA	GO_REF
voltage-gated sodium channel complex	IPI	PMID PMID PMID
plasma membrane	IDA	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated sodium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse

Displaying **all 5** entries
GO Term	Evidence Code	Reference
sodium channel regulator activity	IDA	PMID
sodium channel regulator activity	IBA	GO_REF
sodium channel regulator activity	IEA	GO_REF GO_REF
voltage-gated sodium channel activity involved in cardiac muscle cell action potential	IEA	GO_REF
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	IEA	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

molecular function regulator activity [inference]

transporter regulator activity [inference]

channel regulator activity [inference]

ion channel regulator activity [inference]

sodium channel regulator activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNHKQFSLNWTYQECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNPDDGAK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	Source
42	N-linked (GlcNAc...) asparagine		UniProt GlyGen
66	N-linked (GlcNAc...) asparagine	30765606	UniProt GlyGen
74	N-linked (GlcNAc...) asparagine		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Interaction between L1 and Ankyrins	Homo sapiens
Phase 0 - rapid depolarisation	Homo sapiens
Sensory perception of sweet, bitter, and umami (glutamate) taste	Homo sapiens