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Phase 0 - rapid depolarisation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5576892

PubChem

R-HSA-5576892

Description

Phase 0 is the rapid depolarisation phase in which electrical stimulation of a cell initiates events involving the influx and efflux of ions resulting in the production of a cell's action potential. The cell's excitation opens the closed, fast Na+ channel proteins, causing a large influx of Na+ creating a Na+ current (I_Na+). This causes depolarisation of the cell then voltage-dependent L-type calcium channels (LTCCs) transport Ca2+ into excitable cells. The slope of phase 0 represents the maximum rate of potential change and differs in contractile and pacemaker cells. The potential in this phase changes from around -90mV to around +50mV (Park & Fishman 2011, Grant 2009).

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SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 24 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O60939	Sodium channel regulatory subunit beta-2	SCN2B UNQ326/PRO386	view
P35498	Sodium channel protein type 1 subunit alpha	NAC1 SCN1 SCN1A	view
P35499	Sodium channel protein type 4 subunit alpha	SCN4A	view
Q01118	Sodium channel protein type 7 subunit alpha	SCN6A SCN7A	view
Q02641	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1 CACNLB1	view
Q07699	Sodium channel regulatory subunit beta-1	SCN1B	view
Q08289	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2 CACNLB2 MYSB	view
Q13554	Calcium/calmodulin-dependent protein kinase type II subunit beta	CAM2 CAMK2 CAMK2B CAMKB	view
Q13555	Calcium/calmodulin-dependent protein kinase type II subunit gamma	CAMK CAMK-II CAMK2G CAMKG	view
Q13557	Calcium/calmodulin-dependent protein kinase type II subunit delta	CAMK2D CAMKD	view

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