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Kininogen-1

Summary

UniProt ID: P01042
Gene Symbol: KNG1 BDK KNG
Gene ID: 3827
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011296

GlyConnect

Kininogen-1

GlyGen

P01042

PubChem

P01042

The Human Metabolome Database

HMDBP02063

RaftProt

P01042

Re-Glyco

P01042

Annotation

Keyword: 3D-structure Alternative splicing Blood coagulation Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hydroxylation Inflammatory response Phosphoprotein Proteomics identification Pyrrolidone carboxylic acid Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasodilator

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
inflammatory response
negative regulation of cell adhesion	IDA	PMID
negative regulation of cell adhesion	IBA	GO_REF
negative regulation of cell adhesion	IEA	GO_REF
positive regulation of cytosolic calcium ion concentration	IDA	PMID

GO Hierarchy

biological process

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

coagulation [inference]

blood coagulation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of cell adhesion [inference]

negative regulation of cell adhesion

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell adhesion

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of coagulation [inference]

negative regulation of blood coagulation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

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GO Term	Evidence Code	Reference
extracellular region	NAS	PMID
extracellular region	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome
extracellular region	IDA	PMID
extracellular region	IBA	GO_REF
extracellular region	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

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GO Term	Evidence Code	Reference
cysteine-type endopeptidase inhibitor activity	IDA	PMID
cysteine-type endopeptidase inhibitor activity	IBA	GO_REF
cysteine-type endopeptidase inhibitor activity	IEA	GO_REF GO_REF
signaling receptor binding	IPI	PMID
hormone activity	IDA	PMID PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

cysteine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

cysteine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

cysteine-type endopeptidase inhibitor activity

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

cysteine-type endopeptidase inhibitor activity

Gene Ontology information from UniProt.

Site Annotations

Displaying 1 entry
Position	Description
48	Not glycosylated

Annotation information from UniProt.

Sequence

MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAALKKYNSQNQSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFSVATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQLRIASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKLGQSLDCNAEVYVVPWEKKIYPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTVSPPHTSMAPAQDEERDSGKEQGHTRRHDWGHEKQRKHNLGHGHKHERDQGHGHQRGHGLGHGHEQQHGLGHGHKFKLDDDLEHQGGHVLDHGHKHKHGHGHGKHKNKGKKNGKHNGWKTEHLASSSEDSTTPSAQTQEKTEGPTPIPSLAKPGVTVTFSDFQDSDLIATMMPPISPAPIQSDDDWIPDIQIDPNGLSFNPISDFPDTTSPKCPGRPWKSVSEINPTTQMKESYYFDLTDGLS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 32 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
48	N-linked (GlcNAc...) (complex) asparagine	16335952 19139490 23090970 25265424 29391424 29671580 29741879 37074911	G56518TU G70232NH G70888PK G33791AF G06247RL G47518TP G57776ZS G86880BF G27947YN G22310AV G45395BF G88374WZ G40574BA G08918WF G00912UN G48414YA G46691LC G70619PT G06356OH G59626AS G62765YT G22140GZ G50045TK G11314AS G36379GD G92275SC G28681TP	GlycoProtDB UniProt GlyGen GlyConnect
120		30459171	G53434XO	GlyGen
137		26598643 30459171	G57317CE G23729WG G53434XO G17015OC G58001LT G43417UB G29068FM	GlyGen
150		26598643 30459171	G53434XO G17015OC G58001LT G43417UB	GlyGen
151		26598643 30459171	G17015OC G43417UB G29068FM	GlyGen
169	N-linked (GlcNAc...) asparagine	14760718 16335952 19159218 23090970 24530628 25265424 29391424 29671580 29741879 34725484 3484703 37074911	G69834CE G95678HJ G11115RO G66088HZ G12793SR G99679NM G63136LV G52890YB G30740WO G15169WU G70232NH G94917XT G79286RS G70888PK G06247RL G47518TP G12261QD G22276PO G11629QQ G85144OK G30769VJ G44576HQ G44753VC G77669RF G27947YN G52527GH G30248BL G26267FS G90093AU G40206WX G37692EO G33416PL G63980BQ G04854VP G94470IW G87123QX G79666IR G86752LQ G47012YE G62165AG G20706XG G66163OV G40926MX G43223CG G58954YZ G26330YA G40574BA G82830MN G08918WF G00912UN G48414YA G11911BT G87389XI G23505EP G92551JA G61256FT G72797UR G78644BR G20425TQ G36131WL G72747WU G06356OH G59626AS G25079LO G10486CT G22140GZ G50045TK G89045VA G98129XB	GlycoProtDB UniProt GlyGen GlyConnect
180		14977046		GlyGen
205	N-linked (GlcNAc...) (complex) asparagine	16335952 19139490 19159218 23090970 24417605 24530628 25265424 29391424 29671580 29741879 30237853 3484703 37074911	G53075ES G09831WQ G11115RO G81637OR G99679NM G32788FZ G56518TU G60967DT G78649WQ G76417NN G15169WU G70232NH G94917XT G14547CB G70888PK G92081HT G33791AF G06247RL G47518TP G61806WR G75568BH G80075MS G11629QQ G57776ZS G85144OK G99668VU G86795LJ G86880BF G27947YN G52527GH G30248BL G56784JY G20528HD G04854VP G94470IW G79666IR G81263BG G86752LQ G92135MA G98611JV G40834TG G22310AV G45395BF G88374WZ G59324HL G07246CJ G40926MX G59536GA G26330YA G10846ZT G40574BA G82830MN G00273SJ G08918WF G00912UN G48414YA G27915IV G11911BT G61256FT G72797UR G78644BR G76295SF G27126ED G08293MJ G27058EU G84452RH G96091TT G20425TQ G36131WL G86182NS G72747WU G70619PT G06356OH G59626AS G80920RR G01485JJ G42124LM G90659AW G77547TA G45504EY G64409MC G62765YT G11870QZ G10486CT G22140GZ G50045TK G85269DF G95865ZB G31852PQ G72787SB G23719VF G11314AS G22572EH G57776ZU G57317CE G92275SC G28681TP G89045VA	GlycoProtDB UniProt GlyGen GlyConnect
273		30459171	G43417UB G29068FM	GlyGen
294	N-linked (GlcNAc...) (complex) asparagine	12754519 14760718 16335952 19139490 19159218 19838169 23090970 24279413 24530628 25265424 29391424 29671580 29741879 30237853 32125861 37074911	G26377UA G97968CT G13910DJ G53075ES G69834CE G11115RO G39170TE G76915KR G30221QT G39595FH G81637OR G07810QS G23811SR G32788FZ G56518TU G64394MX G78649WQ G18590ZR G46665ZP G12341GU G76417NN G15169WU G70232NH G94917XT G37818NZ G14547CB G81124ET G70888PK G92081HT G03644CB G33791AF G06247RL G47518TP G41346UA G61806WR G80075MS G11629QQ G57776ZS G85144OK G99668VU G86795LJ G86880BF G27947YN G52527GH G90382BL G40206WX G04854VP G76329HL G79666IR G81263BG G26403SG G44778BV G98611JV G43734MM G34989PA G81198YO G15488CF G40834TG G43669FQ G22310AV G45395BF G59324HL G10819WX G66163OV G40926MX G59536GA G26330YA G10846ZT G40574BA G82830MN G93683YO G08918WF G47737VJ G75983OB G00912UN G42358LZ G48414YA G11911BT G08110WX G61256FT G72797UR G78644BR G72667IM G76295SF G27126ED G04657PL G08293MJ G27058EU G84452RH G20425TQ G36131WL G60033FS G86182NS G72747WU G70619PT G06356OH G59626AS G92406TI G80920RR G01485JJ G42124LM G23863VK G31118FR G45504EY G64409MC G62765YT G47644PP G10486CT G22140GZ G50045TK G85269DF G95865ZB G31852PQ G22572EH G57776ZU G28681TP G54010QB	GlycoProtDB UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
FXIIa activates plasma kallikrein-kinin system	Homo sapiens
FXIIa, PKa activate coagulation factors	Homo sapiens
G alpha (i) signalling events	Homo sapiens
G alpha (q) signalling events	Homo sapiens
Peptide ligand-binding receptors	Homo sapiens
Platelet degranulation	Homo sapiens
Post-translational protein phosphorylation	Homo sapiens
Regulation of FXIIa and plasma kallikrein activity	Homo sapiens
Regulation of IGF Activity by IGFBP	Homo sapiens

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111676	high molecular weight kininogen deficiency	Alliance of Genome Resources
DOID:14735	hereditary angioedema	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements