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MIRAGE
Cellular tumor antigen p53
Summary
- UniProt ID
- P04637
- Gene Symbol
-
- P53
- TP53
- Gene ID
- 7157
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Activator
- Alternative promoter usage
- Alternative splicing
- Apoptosis
- Biological rhythms
- Cell cycle
- Cytoskeleton
- DNA-binding
- Direct protein sequencing
- Disease variant
- Endoplasmic reticulum
- Glycoprotein
- Host-virus interaction
- Isopeptide bond
- Li-Fraumeni syndrome
- Metal-binding
- Methylation
- Mitochondrion
- Necrosis
- Nucleus
- Phosphoprotein
- Reference proteome
- Repressor
- Transcription regulation
- Tumor suppressor
- Ubl conjugation
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| chromatin |
| nucleus |
| nucleolus |
| cytoplasm |
| mitochondrial matrix |
| protein-containing complex |
| nucleoplasm |
| endoplasmic reticulum |
| cytosol |
| replication fork |
| GO Term |
|---|
| cis-regulatory region sequence-specific DNA binding |
| core promoter sequence-specific DNA binding |
| protein phosphatase 2A binding |
| disordered domain specific binding |
Sequence
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 81 |
|
|
||
| 121 |
|
|
||
| 149 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Loss of function of TP53 in cancer due to loss of tetramerization ability | Homo sapiens |
| Oncogene Induced Senescence | Homo sapiens |
| Ovarian tumor domain proteases | Homo sapiens |
| Oxidative Stress Induced Senescence | Homo sapiens |
| PI5P Regulates TP53 Acetylation | Homo sapiens |
| PKR-mediated signaling | Homo sapiens |
| Pre-NOTCH Transcription and Translation | Homo sapiens |
| Pyroptosis | Homo sapiens |
| RUNX3 regulates CDKN1A transcription | Homo sapiens |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050866 | oral squamous cell carcinoma | |
| DOID:0050908 | myelodysplastic syndrome | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:0080630 | B-lymphoblastic leukemia/lymphoma | |
| DOID:0111503 | Li-Fraumeni syndrome 1 | |
| DOID:0112182 | mismatch repair cancer syndrome | |
| DOID:10283 | prostate cancer | |
| DOID:10534 | stomach cancer | |
| DOID:1070 | primary open angle glaucoma | |
| DOID:10811 | nasal cavity cancer |
