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MIRAGE
Cellular tumor antigen p53
Summary
- UniProt ID
- P04637
- Gene Symbol
-
- P53
- TP53
- Gene ID
- 7157
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Activator
- Alternative promoter usage
- Alternative splicing
- Apoptosis
- Biological rhythms
- Cell cycle
- Cytoskeleton
- DNA-binding
- Direct protein sequencing
- Disease variant
- Endoplasmic reticulum
- Glycoprotein
- Host-virus interaction
- Isopeptide bond
- Li-Fraumeni syndrome
- Metal-binding
- Methylation
- Mitochondrion
- Necrosis
- Nucleus
- Phosphoprotein
- Reference proteome
- Repressor
- Transcription regulation
- Tumor suppressor
- Ubl conjugation
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| mitochondrion |
| chromatin |
| nucleus |
| nucleolus |
| cytoplasm |
| mitochondrial matrix |
| protein-containing complex |
| nucleoplasm |
| endoplasmic reticulum |
| cytosol |
| GO Term |
|---|
| negative regulation of transcription by RNA polymerase II |
| mitophagy |
| response to ischemia |
Sequence
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 81 |
|
|
||
| 121 |
|
|
||
| 149 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Stabilization of p53 | Homo sapiens |
| TP53 Regulates Metabolic Genes | Homo sapiens |
| TP53 Regulates Transcription of Caspase Activators and Caspases | Homo sapiens |
| TP53 Regulates Transcription of DNA Repair Genes | Homo sapiens |
| TP53 Regulates Transcription of Death Receptors and Ligands | Homo sapiens |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | Homo sapiens |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | Homo sapiens |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | Homo sapiens |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | Homo sapiens |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1115 | sarcoma | |
| DOID:12361 | Graves' disease | |
| DOID:1350 | paranasal sinus benign neoplasm | |
| DOID:13544 | low tension glaucoma | |
| DOID:1612 | breast cancer | |
| DOID:1749 | squamous cell carcinoma | |
| DOID:1793 | pancreatic cancer | |
| DOID:1909 | melanoma | |
| DOID:2513 | basal cell carcinoma | |
| DOID:2531 | hematologic cancer |
