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T-cell surface glycoprotein CD4

Summary

UniProt ID

P05540

Gene Symbol

Gene ID

24932

Organism

Rattus norvegicus (Norway rat)

External Links

GlyConnect

T-cell surface glycoprotein cd4

GlyGen

P05540

PubChem

P05540

Re-Glyco

P05540

Annotation

Keyword

3D-structure
Adaptive immunity
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Palmitate
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 6** entries
GO Term
plasma membrane
endoplasmic reticulum lumen
endoplasmic reticulum membrane
external side of plasma membrane
cell surface
membrane raft

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 31 in total

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GO Term
helper T cell enhancement of adaptive immune response
response to methamphetamine hydrochloride
cellular response to ionomycin
positive regulation of calcium ion transport into cytosol
response to estradiol
positive regulation of MAPK cascade
response to ethanol
positive regulation of calcium-mediated signaling
regulation of calcium ion transport
positive regulation of ERK1 and ERK2 cascade

Displaying entries **1 - 10** of 14 in total

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GO Term
interleukin-16 binding
interleukin-16 receptor activity
lipid binding
coreceptor activity
immunoglobulin binding
enzyme binding
protein kinase binding
identical protein binding
protein homodimerization activity
protein tyrosine kinase binding

Annotation information from UniProt.

Sequence

MCRGFSFRHLLPLLLLQLSKLLVVTQGKTVVLGKEGGSAELPCESTSRRSASFAWKSSDQKTILGYKNKLLIKGSLELYSRFDSRKNAWERGSFPLIINKLRMEDSQTYVCELENKKEEVELWVFRVTFNPGTRLLQGQSLTLILDSNPKVSDPPIECKHKSSNIVKDSKAFSTHSLRIQDSGIWNCTVTLNQKKHSFDMKLSVLGFASTSITAYKSEGESAEFSFPLNLGEESLQGELRWKAEKAPSSQSWITFSLKNQKVSVQKSTSNPKFQLSETLPLTLQIPQVSLQFAGSGNLTLTLDRGILYQEVNLVVMKVTQPDSNTLTCEVMGPTSPKMRLILKQENQEARVSRQEKVIQVQAPEAGVWQCLLSEGEEVKMDSKIQVLSKGLNQTMFLAVVLGSAFSFLVFTGLCILFCVRCRHQQRQAARMSQIKRLLSEKKTCQCSHRMQKSHNLI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
186	N-linked (GlcNAc...) asparagine	2113054		UniProt GlyGen
297	N-linked (GlcNAc...) asparagine	2113054		UniProt GlyGen
334				GlyGen
392	N-linked (GlcNAc...) asparagine			UniProt GlyGen
			G23863VK G78059CC G36191CD G50045TK G16828VN G72735IY G52064IJ G81295CK G08520NM G33609NS G39188ZX G80966KZ G39213VZ G06110VR G55220VL G60145BJ G88673AA G14669DU G22768VO	GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
Alpha-defensins	Rattus norvegicus
Cargo recognition for clathrin-mediated endocytosis	Rattus norvegicus
Clathrin-mediated endocytosis	Rattus norvegicus
Downstream TCR signaling	Rattus norvegicus
Generation of second messenger molecules	Rattus norvegicus
Other interleukin signaling	Rattus norvegicus
PD-1 signaling	Rattus norvegicus
Phosphorylation of CD3 and TCR zeta chains	Rattus norvegicus
Translocation of ZAP-70 to Immunological synapse	Rattus norvegicus

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10303	sialadenitis	Alliance of Genome Resources
DOID:813	septic arthritis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements