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Beta-2 adrenergic receptor

Summary

UniProt ID

P07550

Gene Symbol

ADRB2
ADRB2R
B2AR

Gene ID

154

Organism

Homo sapiens (human)

External Links

GlyGen: P07550
PubChem: P07550
The Human Metabolome Database: HMDBP01634
The O-GlcNAc Database: P07550
Re-Glyco: P07550

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Golgi apparatus
Hydroxylation
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix
Ubl conjugation

Gene Ontology (GO)

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GO Term
neuronal dense core vesicle
nucleus
lysosome
plasma membrane
membrane
receptor complex
endosome
early endosome
Golgi apparatus
apical plasma membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **11 - 20** of 29 in total

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GO Term
negative regulation of multicellular organism growth
adenylate cyclase-activating adrenergic receptor signaling pathway
positive regulation of cold-induced thermogenesis
AMPA selective glutamate receptor signaling pathway
smooth muscle contraction
cell surface receptor signaling pathway
positive regulation of bone mineralization
bone resorption
negative regulation of G protein-coupled receptor signaling pathway
negative regulation of smooth muscle contraction

Displaying **all 8** entries
GO Term
amyloid-beta binding
potassium channel regulator activity
identical protein binding
protein homodimerization activity
protein-containing complex binding
adenylate cyclase binding
beta2-adrenergic receptor activity
norepinephrine binding

Annotation information from UniProt.

Sequence

MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	GlyTouCan ID	Source
6	N-linked (GlcNAc...) asparagine		UniProt GlyGen
15	N-linked (GlcNAc...) asparagine		UniProt GlyGen
146		G49108TO	The O-GlcNAc Database
187			GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Adrenoceptors	Homo sapiens
Cargo recognition for clathrin-mediated endocytosis	Homo sapiens
Clathrin-mediated endocytosis	Homo sapiens
G alpha (s) signalling events	Homo sapiens
Ub-specific processing proteases	Homo sapiens

Disease

Displaying entries **21 - 22** of 22 in total

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DO ID	Disease Name	Source
DOID:9452	steatotic liver disease	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements