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Tumor necrosis factor

Summary

UniProt ID

P16599

Gene Symbol

Tnf
Tnfa
Tnfsf2

Gene ID

24835

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P16599
Re-Glyco: P16599

Annotation

Keyword

Cell membrane
Cytokine
Disulfide bond
Glycoprotein
Myristate
Phosphoprotein
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Gene Ontology (GO)

Displaying **all 9** entries
GO Term
extracellular region
extracellular space
plasma membrane
neuronal cell body
external side of plasma membrane
cell surface
membrane raft
recycling endosome
phagocytic cup

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of **172** in total

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GO Term
positive regulation of leukocyte adhesion to arterial endothelial cell
negative regulation of branching involved in lung morphogenesis
negative regulation of bile acid secretion
positive regulation of cytokine production involved in inflammatory response
regulation of membrane lipid metabolic process
regulation of reactive oxygen species metabolic process
response to hypoxia
positive regulation of cytokine production
leukocyte migration involved in inflammatory response
regulation of immunoglobulin production

Displaying **all 7** entries
GO Term
death receptor agonist activity
protease binding
cytokine activity
tumor necrosis factor receptor binding
identical protein binding
transcription cis-regulatory region binding
receptor ligand activity

Annotation information from UniProt.

Sequence

MSTESMIRDVELAEEALPKKMGGLQNSRRCLCLSLFSFLLVAGATTLFCLLNFGVIGPNKEEKFPNGLPLISSMAQTLTLRSSSQNSSDKPVAHVVANHQAEEQLEWLSQRANALLANGMDLKDNQLVVPADGLYLIYSQVLFKGQGCPDYVLLTHTVSRFAISYQEKVSLLSAIKSPCPKDTPEGAELKPWYEPMYLGGVFQLEKGDLLSAEVNLPKYLDITESGQVYFGVIAL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
83	O-linked (GalNAc...) serine; in soluble form			UniProt
86	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Regulation of TNFR1 signaling	Rattus norvegicus
TNF signaling	Rattus norvegicus
TNFR1-induced NF-kappa-B signaling pathway	Rattus norvegicus
TNFR1-induced proapoptotic signaling	Rattus norvegicus
TNFR1-mediated ceramide production	Rattus norvegicus
TNFR2 non-canonical NF-kB pathway	Rattus norvegicus

Disease

Displaying entries **1 - 10** of 17 in total

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DO ID	Disease Name	Source
DOID:10247	pleurisy	Alliance of Genome Resources
DOID:10762	portal hypertension	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10941	intracranial aneurysm	Alliance of Genome Resources
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:13088	periventricular leukomalacia	Alliance of Genome Resources
DOID:13976	peptic esophagitis	Alliance of Genome Resources
DOID:1686	glaucoma	Alliance of Genome Resources
DOID:224	transient cerebral ischemia	Alliance of Genome Resources
DOID:289	endometriosis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements