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Repository for lectin-assisted multimodality data
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MIRAGE
Tumor necrosis factor
Summary
- UniProt ID
- P16599
- Gene Symbol
-
- Tnf
- Tnfa
- Tnfsf2
- Gene ID
- 24835
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Cell membrane
- Cytokine
- Disulfide bond
- Glycoprotein
- Myristate
- Phosphoprotein
- Reference proteome
- Secreted
- Signal-anchor
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular space |
| plasma membrane |
| neuronal cell body |
| external side of plasma membrane |
| cell surface |
| membrane raft |
| recycling endosome |
| phagocytic cup |
| GO Term |
|---|
| positive regulation of protein localization to cell surface |
| positive regulation of chemokine (C-X-C motif) ligand 2 production |
Sequence
MSTESMIRDVELAEEALPKKMGGLQNSRRCLCLSLFSFLLVAGATTLFCLLNFGVIGPNKEEKFPNGLPLISSMAQTLTLRSSSQNSSDKPVAHVVANHQAEEQLEWLSQRANALLANGMDLKDNQLVVPADGLYLIYSQVLFKGQGCPDYVLLTHTVSRFAISYQEKVSLLSAIKSPCPKDTPEGAELKPWYEPMYLGGVFQLEKGDLLSAEVNLPKYLDITESGQVYFGVIAL
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Regulation of TNFR1 signaling | Rattus norvegicus |
| TNF signaling | Rattus norvegicus |
| TNFR1-induced NF-kappa-B signaling pathway | Rattus norvegicus |
| TNFR1-induced proapoptotic signaling | Rattus norvegicus |
| TNFR1-mediated ceramide production | Rattus norvegicus |
| TNFR2 non-canonical NF-kB pathway | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10247 | pleurisy | |
| DOID:10762 | portal hypertension | |
| DOID:10763 | hypertension | |
| DOID:10941 | intracranial aneurysm | |
| DOID:11832 | visual epilepsy | |
| DOID:13088 | periventricular leukomalacia | |
| DOID:13976 | peptic esophagitis | |
| DOID:1686 | glaucoma | |
| DOID:224 | transient cerebral ischemia | |
| DOID:289 | endometriosis |
