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Glycan Structure Repository
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Glycoconjugate Repository
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Glycomics MS Repository for glycan annotations from GlycoWorkbench
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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Syndecan-4
Summary
- UniProt ID
- P31431
- Gene Symbol
-
- SDC4
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P31431
- PubChem
- P31431
- The Human Metabolome Database
- HMDBP02435
- RaftProt
- P31431
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Heparan sulfate
- Reference proteome
- Secreted
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| plasma membrane |
| extracellular exosome |
| costamere |
| Golgi lumen |
| focal adhesion |
| cell surface |
| lysosomal lumen |
| GO Term |
|---|
| identical protein binding |
| fibronectin binding |
| protein kinase C binding |
| thrombospondin receptor activity |
Sequence
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAALIVGGIVGILFAVFLILLLMYRMKKKDEGSYDLGKKPIYKKAPTNEFYA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 24 |
|
|||
| 39 | O-linked (Xyl...) (glycosaminoglycan) serine |
|
||
| 61 | O-linked (Xyl...) (glycosaminoglycan) serine |
|
||
| 63 | O-linked (Xyl...) (glycosaminoglycan) serine |
|
||
| 93 |
|
|||
| 95 | O-linked (Xyl...) (chondroitin sulfate) serine |
|
||
| 97 |
|
|||
| 101 |
|
|||
| 116 |
|
G43417UB
G57321FI
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| A tetrasaccharide linker sequence is required for GAG synthesis | Homo sapiens |
| Attachment and Entry | Homo sapiens |
| Cell surface interactions at the vascular wall | Homo sapiens |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | Homo sapiens |
| Defective B3GAT3 causes JDSSDHD | Homo sapiens |
| Defective B4GALT7 causes EDS, progeroid type | Homo sapiens |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | Homo sapiens |
| Defective EXT2 causes exostoses 2 | Homo sapiens |
| HS-GAG biosynthesis | Homo sapiens |
| HS-GAG degradation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050156 | idiopathic pulmonary fibrosis | |
| DOID:0060041 | autism spectrum disorder | |
| DOID:0060061 | primary cutaneous T-cell non-Hodgkin lymphoma | |
| DOID:0060180 | colitis | |
| DOID:0060189 | ileitis | |
| DOID:0060190 | ileocolitis | |
| DOID:0080334 | aortic valve disease 2 | |
| DOID:0110227 | cataract 32 multiple types | |
| DOID:0110425 | dilated cardiomyopathy 1A | |
| DOID:10113 | trypanosomiasis |
