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Transcription factor SOX-2
Summary
- UniProt ID
- P48431
- Gene Symbol
- SOX2
- Gene ID
- 6657
- Organism
- Homo sapiens (human)
Annotation
- Keyword
- 3D-structure Activator Cytoplasm DNA-binding Developmental protein Disease variant Isopeptide bond Methylation Microphthalmia Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription regulation Ubl conjugation
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| negative regulation of transcription by RNA polymerase II | ||
| osteoblast differentiation | ||
| eye development | ||
| endodermal cell fate specification |
GO Hierarchy
biological process
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| transcription cis-regulatory region binding | ||
| transcription cis-regulatory region binding | ||
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | ||
| DNA-binding transcription factor activity, RNA polymerase II-specific | ||
| DNA-binding transcription activator activity, RNA polymerase II-specific |
Sequence
MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQSGPVPGTAINGTLPLSHM
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 232 |
|
|
||
| 246 |
|
|||
| 249 |
|
|||
| 250 |
|
|||
| 251 |
|
|||
| 256 |
|
|||
| 257 |
|
|||
| 259 |
|
|||
| 309 |
|
G49108TO
G59324HL
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Deactivation of the beta-catenin transactivating complex | Homo sapiens |
| Formation of the anterior neural plate | Homo sapiens |
| Formation of the posterior neural plate | Homo sapiens |
| Interleukin-4 and Interleukin-13 signaling | Homo sapiens |
| POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | Homo sapiens |
| POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | Homo sapiens |
| Primitive streak formation | Homo sapiens |
| Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition | Homo sapiens |
| Specification of the neural plate border | Homo sapiens |
| Transcriptional Regulation by MECP2 | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1612 | breast cancer | |
| DOID:0111801 | syndromic microphthalmia 3 | |
| DOID:10811 | nasal cavity cancer |
