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3-ketodihydrosphingosine reductase

Summary

UniProt ID: Q06136
Gene Symbol: FVT1 KDSR SDR35C1
Gene ID: 2531
Organism: Homo sapiens (human)

External Links

PubChem

Q06136

SwissLipids

SLP:000000155

The Human Metabolome Database

HMDBP03056

The O-GlcNAc Database

Q06136

Re-Glyco

Q06136

Annotation

Keyword: Alternative splicing Chromosomal rearrangement Disease variant Endoplasmic reticulum NADP Nucleotide-binding Oxidoreductase Palmoplantar keratoderma Proteomics identification Proto-oncogene Reference proteome Signal Sphingolipid metabolism Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
3-keto-sphinganine metabolic process	IDA	PMID
3-keto-sphinganine metabolic process	IMP	PMID
3-keto-sphinganine metabolic process	IBA	GO_REF
3-keto-sphinganine metabolic process	IEA	GO_REF
glycosphingolipid biosynthetic process	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

3-keto-sphinganine metabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process

lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

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GO Term	Evidence Code	Reference
obsolete extracellular space
endoplasmic reticulum	IDA	PMID
endoplasmic reticulum membrane	EXP	PMID PMID
endoplasmic reticulum membrane	TAS	Reactome
endoplasmic reticulum membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane

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GO Term	Evidence Code	Reference
3-dehydrosphinganine reductase activity	EXP	PMID
3-dehydrosphinganine reductase activity	TAS	Reactome
3-dehydrosphinganine reductase activity	IDA	PMID PMID
3-dehydrosphinganine reductase activity	IMP	PMID PMID
3-dehydrosphinganine reductase activity	IEA	GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

3-dehydrosphinganine reductase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

NADPH binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding [inference]

NADPH binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding [inference]

NADPH binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRLISETTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSALTCGMAPVTSITEGLQQVVTMGLFRTIALFYLGSFDSIVRRCMMQREKSENADKTA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
212		38253038 40596516	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Sphingolipid de novo biosynthesis	Homo sapiens

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050873	follicular lymphoma	Alliance of Genome Resources
DOID:0080250	erythrokeratodermia variabilis et progressiva 4	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

Annotation

International Collaboration

Acknowledgements