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MIRAGE
3-ketodihydrosphingosine reductase

Summary
UniProt ID
Q06136
Gene Symbol
  • FVT1
  • KDSR
  • SDR35C1
Gene ID
2531
Organism
Homo sapiens (human)
PubChem
Q06136
SwissLipids
The Human Metabolome Database
HMDBP03056
The O-GlcNAc Database
Q06136
Re-Glyco
Q06136
Annotation
Keyword
  • Alternative splicing
  • Chromosomal rearrangement
  • Disease variant
  • Endoplasmic reticulum
  • NADP
  • Nucleotide-binding
  • Oxidoreductase
  • Palmoplantar keratoderma
  • Proto-oncogene
  • Reference proteome
  • Signal
  • Sphingolipid metabolism
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 4 entries
GO Term
extracellular space
membrane
endoplasmic reticulum
endoplasmic reticulum membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying all 2 entries
GO Term
3-dehydrosphinganine reductase activity
NADPH binding
Annotation information from UniProt.
Sequence
MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRLISETTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSALTCGMAPVTSITEGLQQVVTMGLFRTIALFYLGSFDSIVRRCMMQREKSENADKTA
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying 1 entry
Position Description PubMed ID GlyTouCan ID Source
212
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying 1 entry
Pathway Name Organism
Sphingolipid de novo biosynthesis Homo sapiens
Disease
Displaying all 2 entries
DO ID Disease Name Source
DOID:0050873 follicular lymphoma
DOID:0080250 erythrokeratodermia variabilis et progressiva 4
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025