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Sphingolipid de novo biosynthesis

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-1660661

PubChem

R-HSA-1660661

Description

Glycosphingolipid biosynthesis is based on salvage of sphingolipids and de novo sphingolipid synthesis. Sphingoid-1-phosphate signalling molecules are synthesized through the same pathway, which starts with the transfer of a fatty acid onto serine. The diversity of products results from later dehydrogenation or hydroxylation of fatty acid moieties, as well as the usage of fatty acids of different lengths. Biosynthesis takes place in the endoplasmic reticulum lumen and the cytosol. Lipophilic products are transported to other membranes via a specialized transporter (CERT1) or the secretory pathway. Soluble sphingoid-1-phosphates are exported by multiple transporters in the plasma membrane (reviewed by Merrill 2002, Gault et al. 2010).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 15 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A6NFX1	Sphingosine-1-phosphate transporter MFSD2B	MFSD2B	view
O95292	Vesicle-associated membrane protein-associated protein B/C	UNQ484/PRO983 VAPB	view
P22059	Oxysterol-binding protein 1	OSBP OSBP1	view
P33527	Multidrug resistance-associated protein 1	ABCC1 MRP MRP1	view
Q06136	3-ketodihydrosphingosine reductase	FVT1 KDSR SDR35C1	view
Q5SGD2	Protein phosphatase 1L	PP2CE PPM1L	view
Q6ZMG9	Ceramide synthase 6	CERS6 LASS6	view
Q7L5A8	Fatty acid 2-hydroxylase	FA2H FAAH FAXDC1	view
Q8IVW8	Sphingosine-1-phosphate transporter SPNS2	SPNS2	view
Q8N5B7	Ceramide synthase 5	CERS5 LASS5	view

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