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Inter-alpha-trypsin inhibitor heavy chain H4

Summary

UniProt ID: Q14624
Gene Symbol: ITIH4 IHRP ITIHL1 PK120 PRO1851
Gene ID: 3700
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011904

GlyConnect

Inter-alpha-trypsin inhibitor heavy chain h4

GlyGen

Q14624

The O-GlcNAc Database

Q14624

RaftProt

Q14624

Re-Glyco

Q14624

Annotation

Keyword: 3D-structure Acute phase Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Proteomics identification Reference proteome Secreted Serine protease inhibitor Signal

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	Reference
acute-phase response	IEP	PMID
hyaluronan metabolic process	IEA	GO_REF
response to cytokine	IEP	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

glycosaminoglycan metabolic process [inference]

hyaluronan metabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

glycosaminoglycan metabolic process [inference]

hyaluronan metabolic process

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response [inference]

acute-phase response

response to chemical [inference]

response to peptide [inference]

response to cytokine

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
extracellular region	NAS	PMID
extracellular region	TAS	Reactome
extracellular region	IEA	GO_REF GO_REF
plasma membrane
extracellular matrix	HDA	PMID PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet dense granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet dense granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

Displaying **all 2** entries
GO Term	Evidence Code	Reference
endopeptidase inhibitor activity	TAS	PMID
serine-type endopeptidase inhibitor activity	IEA	GO_REF

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKPPRPVRTCSKVLVLLSLLAIHQTTTAEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMIIDGMTYPGIIKEKAEAQAQYSAAVAKGKSAGLVKATGRNMEQFQVSVSVAPNAKITFELVYEELLKRRLGVYELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNQLVDALTTWQNKTKAHIRFKPTLSQQQKSPEQQETVLDGNLIIRYDVDRAISGGSIQIENGYFVHYFAPEGLTTMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLVPASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGDPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHEDSDSALQLQDFYQEVANPLLTAVTFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPDVLTATVSGKLPTQNITFQTESSVAEQEAEFQSPKYIFHNFMERLWAYLTIQQLLEQTVSASDADQQALRNQALNLSLAYSFVTPLTSMVVTKPDDQEQSQVAEKPMEGESRNRNVHSGSTFFKYYLQGAKIPKPEASFSPRRGWNRQAGAAGSRMNFRPGVLSSRQLGLPGPPDVPDHAAYHPFRRLAILPASAPPATSNPDPAVSRVMNMKIEETTMTTQTPAPIQAPSAILPLPGQSVERLCVDPRHRQGPVNLLSDPEQGVEVTGQYEREKAGFSWIEVTFKNPLVWVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDPDKVTIGLLFWDGRGEGLRLLLRDTDRFSSHVGGTLGQFYQEVLWGSPAASDDGRRTLRVQGNDHSATRERRLDYQEGPPGVEISCWSVEL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 16 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
11		38253038	G49108TO	The O-GlcNAc Database
81	N-linked (GlcNAc...) asparagine	16335952 19159218 23090970 24884609 29391424 29671580 29741879 30237853 34725484 37074911	G60967DT G78649WQ G70232NH G69521XL G14547CB G70888PK G06247RL G47518TP G93860XO G68490OW G27947YN G52527GH G63980BQ G04854VP G47748JZ G40834TG G45395BF G85554PZ G40926MX G14972EH G43223CG G58954YZ G37412TK G31986NC G26330YA G10846ZT G40574BA G82830MN G78787DI G00273SJ G08918WF G47737VJ G75983OB G00912UN G42358LZ G48414YA G49906RN G78790NZ G58087IP G11911BT G27126ED G20425TQ G36131WL G86182NS G49018RC G72747WU G70619PT G06356OH G37868ZX G59626AS G01650EU G23294PN G79568CQ G94120DZ G03081ER G03382KH G23863VK G57818FI G84820NF G14260UH G23432EQ G56238AO G10486CT G22140GZ G50045TK G95865ZB G75798PH G81295CK G22572EH G39188ZX G80966KZ G39943KJ G06110VR G55220VL G54010QB G84225JN	GlycoProtDB UniProt GlyGen GlyConnect
207	N-linked (GlcNAc...) asparagine	12754519 16335952 19159218 24884609 29671580	G08146BT G22310AV G59411JK G95977AE G00912UN G42358LZ G48414YA G56069TX G72667IM G45495MK G84452RH G78261DB G91636VS G68800OF G70418MS G42962KI G44215PV G03081ER G03382KH G23863VK G57818FI G10486CT G46687AB G61937QU G49874UX G56903ZB	GlycoProtDB UniProt GlyGen GlyConnect
274	N-linked (GlcNAc...) asparagine; atypical	24884609	G64527OM G66676MI G05724UK G82020ZR G39188ZX G80966KZ G06110VR G55220VL	UniProt GlyGen GlyConnect
517	N-linked (GlcNAc...) asparagine	14760718 16335952 19159218 23090970 24279413 24530628 24884609 29391424 29671580 29741879 37074911	G13165FV G69834CE G12793SR G83213GG G24303GI G55412XP G56518TU G64394MX G83295QG G12341GU G15169WU G51941GC G70232NH G94917XT G31153XO G37818NZ G93656SY G14547CB G70888PK G92081HT G03644CB G90386IR G06247RL G47518TP G93860XO G34617SM G68209WQ G80075MS G11629QQ G57776ZS G79939YZ G85144OK G75418YA G99668VU G77669RF G60834IK G20076CD G86795LJ G86880BF G27947YN G52527GH G06192YD G91473PK G27102CT G90093AU G24954UD G60070LT G63980BQ G04854VP G94470IW G32246SI G81263BG G40834TG G43669FQ G08146BT G22310AV G45395BF G88374WZ G59324HL G85554PZ G10819WX G16758MX G40926MX G59536GA G02030ZB G99950SF G31986NC G26330YA G10846ZT G40574BA G82830MN G05933EN G08918WF G47737VJ G71146HJ G75983OB G00912UN G42358LZ G48414YA G58087IP G11911BT G65186XA G72797UR G70822IO G88325OQ G56069TX G72667IM G15664MX G27126ED G27058EU G45495MK G84452RH G78261DB G91636VS G68800OF G70418MS G49018RC G72747WU G42962KI G44215PV G70619PT G06356OH G37868ZX G59626AS G05642HQ G14994KB G03081ER G03382KH G23863VK G57818FI G90659AW G31916IQ G83204BU G83633GK G62765YT G10256JP G15828HX G10486CT G46687AB G61937QU G85269DF G95865ZB G49874UX G56903ZB G28681TP G54010QB G65344XH	GlycoProtDB UniProt GlyGen GlyConnect
577	N-linked (GlcNAc...) asparagine	16335952 24884609 29671580 30237853	G39595FH G90789YQ G31665QC G78166NF G64394MX G83295QG G15169WU G51941GC G94917XT G55216FT G06247RL G47518TP G93860XO G34617SM G68209WQ G87015RU G97876DH G11629QQ G79939YZ G85144OK G27947YN G52527GH G24954UD G60070LT G32246SI G81263BG G08146BT G22310AV G00912UN G42358LZ G48414YA G44211QA G56069TX G72667IM G45495MK G84452RH G60033FS G59626AS G03081ER G03382KH G23863VK G57818FI G10486CT G46687AB G61937QU G49874UX G56903ZB	UniProt GlyGen GlyConnect
640		26598643	G17015OC	GlyGen
701		30459171	G58001LT G27391WQ G43417UB G29068FM	GlyGen
702		30459171	G43417UB G29068FM	GlyGen
709		30237853		GlyConnect