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Protein RCC2

Summary

UniProt ID: Q8BK67
Gene Symbol: Kiaa1470 Rcc2
Gene ID: 108911
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q8BK67
PubChem: Q8BK67
The O-GlcNAc Database: Q8BK67
Re-Glyco: Q8BK67

Annotation

Keyword: Acetylation Cell membrane Centromere Chromosome Cytoskeleton Guanine-nucleotide releasing factor Microtubule Mitosis Nucleus Phosphoprotein Reference proteome Repeat

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	Reference
integrin-mediated signaling pathway	ISO	GO_REF
integrin-mediated signaling pathway	IEA	GO_REF
regulation of fibroblast migration	IMP	PMID
positive regulation of G2/M transition of mitotic cell cycle	ISO	GO_REF
positive regulation of G2/M transition of mitotic cell cycle	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

cell-substrate junction organization [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region [inference]

protein localization to kinetochore [inference]

chromosome passenger complex localization to kinetochore

protein localization to condensed chromosome [inference]

protein localization to kinetochore [inference]

chromosome passenger complex localization to kinetochore

protein-containing complex localization [inference]

chromosome passenger complex localization to kinetochore

establishment of localization [inference]

establishment of protein localization

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

regulation of fibroblast migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of chromosome segregation [inference]

positive regulation of attachment of spindle microtubules to kinetochore

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

negative regulation of biological process [inference]

negative regulation of GTPase activity

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion [inference]

negative regulation of focal adhesion assembly

negative regulation of substrate adhesion-dependent cell spreading

negative regulation of cellular component organization [inference]

negative regulation of cell-substrate junction organization [inference]

negative regulation of focal adhesion assembly

negative regulation of cell junction assembly [inference]

negative regulation of focal adhesion assembly

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion [inference]

negative regulation of focal adhesion assembly

negative regulation of substrate adhesion-dependent cell spreading

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

negative regulation of cell-matrix adhesion [inference]

negative regulation of focal adhesion assembly

regulation of focal adhesion assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion [inference]

negative regulation of focal adhesion assembly

negative regulation of substrate adhesion-dependent cell spreading

regulation of substrate adhesion-dependent cell spreading [inference]

negative regulation of substrate adhesion-dependent cell spreading

regulation of cellular component biogenesis [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of ruffle assembly

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of cell junction assembly [inference]

negative regulation of focal adhesion assembly

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of chromosome segregation [inference]

positive regulation of attachment of spindle microtubules to kinetochore

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion [inference]

negative regulation of focal adhesion assembly

negative regulation of substrate adhesion-dependent cell spreading

negative regulation of cellular component organization [inference]

negative regulation of cell-substrate junction organization [inference]

negative regulation of focal adhesion assembly

negative regulation of cell junction assembly [inference]

negative regulation of focal adhesion assembly

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of ruffle assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of ruffle assembly

negative regulation of cellular component organization [inference]

negative regulation of cell-substrate junction organization [inference]

negative regulation of focal adhesion assembly

negative regulation of cell junction assembly [inference]

negative regulation of focal adhesion assembly

regulation of cell-substrate junction organization [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of cell-substrate junction organization [inference]

negative regulation of focal adhesion assembly

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of cell junction assembly [inference]

negative regulation of focal adhesion assembly

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cell cycle process [inference]

regulation of chromosome segregation [inference]

positive regulation of chromosome segregation [inference]

positive regulation of attachment of spindle microtubules to kinetochore

regulation of attachment of spindle microtubules to kinetochore [inference]

positive regulation of attachment of spindle microtubules to kinetochore

positive regulation of cell cycle process [inference]

positive regulation of chromosome segregation [inference]

positive regulation of attachment of spindle microtubules to kinetochore

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cell cycle phase transition [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cell cycle G2/M phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of chromosome segregation [inference]

positive regulation of attachment of spindle microtubules to kinetochore

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cell motility [inference]

regulation of cell migration

regulation of fibroblast migration

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

negative regulation of GTPase activity

positive regulation of GTPase activity [inference]

activation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	Reference
nucleus	ISS	GO_REF
nucleus	ISO	GO_REF
nucleus	IDA	PMID
nucleus	IEA	GO_REF
nucleolus	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

midbody

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nucleolus

spindle midzone [inference]

mitotic spindle midzone

chromosomal region [inference]

chromosome, centromeric core domain

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
guanyl-nucleotide exchange factor activity
microtubule binding	ISO	GO_REF
microtubule binding	IEA	GO_REF
protein kinase binding	ISO	GO_REF
protein kinase binding	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

GTPase binding [inference]

small GTPase binding

protein domain specific binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPRKKGAAWEEPSSGNGTARAGPRRRGGPAGRKRERPERCSSSSGGGSSGDEDGPELDGAPGGGKRTARPATAGKAAGAAAIITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLSGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMLMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESEAEKEKLQRLPEYTPRTL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	PubMed ID	GlyTouCan ID	Source
16		G80920RR	GlyGen
210		G29184RN	GlyGen
351	22645316 25153642 28135057 28528544 34887587 37507081 39627609 40021952	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	Mus musculus
EML4 and NUDC in mitotic spindle formation	Mus musculus
Mitotic Prometaphase	Mus musculus
RHO GTPases Activate Formins	Mus musculus
Resolution of Sister Chromatid Cohesion	Mus musculus
Separation of Sister Chromatids	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

International Collaboration

Acknowledgements