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Sodium-coupled monocarboxylate transporter 1

Summary

UniProt ID: Q8N695
Gene Symbol: AIT SLC5A8 SMCT SMCT1
Gene ID: 160728
Organism: Homo sapiens (human)

External Links

GlyGen: Q8N695
PubChem: Q8N695
The Human Metabolome Database: HMDBP08227
Re-Glyco: Q8N695

Annotation

Keyword: 3D-structure Apoptosis Cell membrane Glycoprotein Proteomics identification Reference proteome Sodium transport Symport Transmembrane helix Tumor suppressor

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
sodium ion transport	IBA	GO_REF
chloride transport	IDA	PMID
acetate transport	IDA	PMID PMID
pyruvate transport	IDA	PMID PMID PMID PMID
apoptotic process

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

alkaloid metabolic process [inference]

nicotinate metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

nicotinate metabolic process

pyridine-containing compound metabolic process [inference]

nicotinate metabolic process

cell death [inference]

programmed cell death [inference]

apoptotic process

transmembrane transport [inference]

nitrate transmembrane transport

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

short-chain fatty acid transmembrane transport [inference]

propanoate transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

monoatomic anion transport [inference]

lipid transport [inference]

fatty acid transport [inference]

short-chain fatty acid transport [inference]

short-chain fatty acid transmembrane transport [inference]

propanoate transmembrane transport

fatty acid transmembrane transport [inference]

short-chain fatty acid transmembrane transport [inference]

propanoate transmembrane transport

inorganic anion transport [inference]

nitrate import [inference]

nitrate transmembrane transport

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

short-chain fatty acid transport [inference]

short-chain fatty acid transmembrane transport [inference]

propanoate transmembrane transport

fatty acid transmembrane transport [inference]

short-chain fatty acid transmembrane transport [inference]

propanoate transmembrane transport

nicotinate transport

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

short-chain fatty acid transmembrane transport [inference]

propanoate transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

short-chain fatty acid transport [inference]

short-chain fatty acid transmembrane transport [inference]

propanoate transmembrane transport

fatty acid transmembrane transport [inference]

short-chain fatty acid transmembrane transport [inference]

propanoate transmembrane transport

nicotinate transport

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

short-chain fatty acid transmembrane transport [inference]

propanoate transmembrane transport

organic hydroxy compound transport [inference]

lactate transport

transmembrane transport [inference]

nitrate transmembrane transport

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

short-chain fatty acid transmembrane transport [inference]

propanoate transmembrane transport

nitrogen compound transport [inference]

nitrate import [inference]

nitrate transmembrane transport

nicotinate transport

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
GINS complex	IEA	GO_REF
plasma membrane	TAS	Reactome Reactome
plasma membrane	IBA	GO_REF
apical plasma membrane	EXP	PMID
apical plasma membrane	IDA	PMID PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

DNA replication preinitiation complex [inference]

GINS complex

nuclear protein-containing complex [inference]

DNA replication preinitiation complex [inference]

GINS complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
organic acid:sodium symporter activity	IBA	GO_REF
organic acid:sodium symporter activity	IEA	GO_REF
monocarboxylic acid transmembrane transporter activity	TAS	Reactome
lactate transmembrane transporter activity	IEA	GO_REF
propionate transmembrane transporter activity	IEA	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

iodide channel activity

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity

monocarboxylate:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity

monocarboxylate:sodium symporter activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

iodide channel activity

iodide transmembrane transporter activity [inference]

iodide channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

iodide channel activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity

monocarboxylate:sodium symporter activity

secondary active monocarboxylate transmembrane transporter activity [inference]

monocarboxylate:sodium symporter activity

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity

lactate transmembrane transporter activity

fatty acid transmembrane transporter activity [inference]

short-chain fatty acid transmembrane transporter activity [inference]

propionate transmembrane transporter activity

secondary active monocarboxylate transmembrane transporter activity [inference]

monocarboxylate:sodium symporter activity

nicotinate transmembrane transporter activity

lipid transmembrane transporter activity [inference]

fatty acid transmembrane transporter activity [inference]

short-chain fatty acid transmembrane transporter activity [inference]

propionate transmembrane transporter activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDTPRGIGTFVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKDFLMGGRRMTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFTYFFVVVISAEVFLPVFYKLGITSTYEYLELRFNKCVRLCGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFASVIIQAVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRHTFWTIIIGGTFTWTSIYGVNQSQVQRYISCKSRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPWTAKKVSAPDQLMPYLVLDILQDYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERSLSWISQGMSVVYGALCIGMAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGFAISLWVGIGAQIYPPLPERTLPLHLDIQGCNSTYNETNLMTTTEMPFTTSVFQIYNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLSTGGRKQNLDPRYILTKEDFLSNFDIFKKKKHVLSYKSHPVEDGGTDNPAFNHIELNSDQSGKSNGTRL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites