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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Glutathione hydrolase 1 proenzyme
Summary
- UniProt ID
- P19440
- Gene Symbol
-
- GGT1
- GGT
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011591
- GlyConnect
- GlyGen
- P19440
- PubChem
- P19440
- SwissLipids
- The Human Metabolome Database
- HMDBP00730
- RaftProt
- P19440
Annotation
- Keyword
-
- 3D-structure
- Acyltransferase
- Alternative promoter usage
- Alternative splicing
- Cell membrane
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glutathione biosynthesis
- Intellectual disability
- Lipid metabolism
- Protease
- Reference proteome
- Sialic acid
- Signal-anchor
- Transmembrane helix
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| cysteine biosynthetic process |
| peptide modification |
| leukotriene metabolic process |
| glutathione catabolic process |
| GO Term |
|---|
| extracellular space |
| plasma membrane |
| extracellular exosome |
| GO Term |
|---|
| glutathione hydrolase activity |
| peptidyltransferase activity |
| leukotriene-C(4) hydrolase |
| leukotriene C4 gamma-glutamyl transferase activity |
Sequence
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSRESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| APAP ADME | Homo sapiens |
| Aflatoxin activation and detoxification | Homo sapiens |
| Defective GGT1 causes GLUTH | Homo sapiens |
| Defective GGT1 in aflatoxin detoxification causes GLUTH | Homo sapiens |
| Glutathione synthesis and recycling | Homo sapiens |
| LTC4-CYSLTR mediated IL4 production | Homo sapiens |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050908 | myelodysplastic syndrome | |
| DOID:0060058 | lymphoma | |
| DOID:0060224 | atrial fibrillation | |
| DOID:0060262 | gallbladder disease | |
| DOID:0060449 | gelatinous drop-like corneal dystrophy | |
| DOID:0070221 | progressive familial intrahepatic cholestasis | |
| DOID:0070226 | progressive familial intrahepatic cholestasis 1 | |
| DOID:0070230 | benign recurrent intrahepatic cholestasis | |
| DOID:0080144 | childhood acute lymphocytic leukemia | |
| DOID:0080199 | colorectal carcinoma |
